注射用硫酸头孢噻利与3种常用输液配伍的稳定性考察  

Study on the Stability of the compatibility of Cefoselis Sulfate for Injection with 3 kinds of injections

作　　者：夏辉[1] 高静[2] 

机构地区：[1]江苏省徐州市第一人民医院药剂科,221002 [2]徐州医学院附属医院药剂科,江苏省徐州市221002

出　　处：《临床合理用药杂志》2013年第32期31-32,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的考察注射用硫酸头孢噻利与0.9%氯化钠注射液、5%葡萄糖注射液、葡萄糖氯化钠注射液的配伍稳定性。方法建立注射用硫酸头孢噻利在3种输液中的紫外分光光度法含量测定方法,分析混合液在25℃条件下6h内药物含量,并观察其外观、pH值及紫外光谱变化,采用紫外分光光度法测定配伍液中硫酸头孢噻利含量。结果 6h内配伍液外观、pH及含量基本保持不变。结论注射用硫酸头孢噻利与3种输液的配伍液在6h内稳定,可以配伍使用。Objective To investigate the stability of the compatibility of cefoselis sulfate for injection when mixed with 0.9% Nacl injection,5% glucose injection and glucose saline. Methods The UV method for determination of cefoselis sulfate and three injection in their mixed solution were established,by which they were assayed at 25℃ during 6h. The appear- mace, PH values and UV spectrum of the mixed solution were also examined. Results There were no significant changes with- in 6 hours in terms of the appearance,pH value,content and the ultraviolet absorption. Conclusion Cefoselis sulsate injection can be used together with the three injection within 6 hours.

关 键 词：硫酸头孢噻利 注射液配伍 稳定性 紫外分光光度法 

分 类 号：R942[医药卫生—药剂学]