2型糖尿病伴左室舒张功能不全患者心率变异性与B型尿钠肽的相关性分析  

Study on correlation between brain natriuretic peptide and heart rate variability in patients with type 2 diabetes and left ventricular diastolic dysfunction

作　　者：杨燕华[1] 刘自爱[1] 黄庆宁[1] 黄虔[1] 

机构地区：[1]东莞市人民医院心内科,523000

出　　处：《国际医药卫生导报》2013年第24期3693-3696,共4页International Medicine and Health Guidance News

基　　金：东莞市科技计划医疗卫生类科研项目（201110515001101）

摘　　要：目的 分析2型糖尿病伴左室舒张功能不全患者心率变异性与B型尿钠肽的关系.方法 收集100例B型尿钠肽≥100 pg/ml的2型糖尿病患者,研究其心率变异性与B型尿钠肽的相关性.心率变异性指标包括：SDNN-Index、RMSSD、PNN50,数据以平均值±标准差（M±SD）表示,用SPSS软件进行Pearson相关分析.结果 100例2型糖尿病伴心脏舒张功能不全患者SDNN-Index为（46.41±17.74） ms,RMSSD为（37.18±19.07） ms,PNN50为（18.88±15.21）％,SDNN-Index、RMSSD、PNN50与B型尿钠肽相关系数分别为-0.472、-0.434、-0.589,P均＜0.01.结论 2型糖尿病伴心脏舒张功能不全患者的心率变异性明显低于正常人,且与B型尿钠肽水平相关.Objective To evaluate the correlation between heart rate variability and brain natriuretic peptide （BNP） in patients with type 2 diabetes and left ventricular diastolic dysfunction. Methods 100 patients with type 2 diabetes were included, all the patients＇ BNP level were over 100 pg/ml. SDNN-Index, RMSSD, PNN50 and BNP were measured, data were presented as （ M ± SD ） . The correlation between heart rate variability and BNP level was assessed by Pearson Correlation Analysis （SPSS software）. Results The correlation coefficient between SDNN-Index [（46.41 ± 17.74） ms] and BNP level was -0.472 （P 〈 0.01）; The correlation coefficient between RMSSD [（37.18 ±19.07） ms] and BNP level was -0.434 （P 〈 0.01）; the correlation coefficient between PNN50[（18.88±15.21）%] and BNP level was -0.589 （P 〈 0.01）. Conclusion The heart rate variability in patients with type 2 diabetes and left ventricular diastolic dysfunction is obviously lower than that of normal people, and significantly correlated with BNP level.

关 键 词：2型糖尿病 左室舒张功能不全 心率变异性 B型尿钠肽 

分 类 号：R587.1[医药卫生—内分泌]