Proliferation and differentiation of mouse embryonic stem cells lacking all lamins  

作　　者：YoungjoKim[1]  XiaobinZheng[1] YixianZheng[1] 

出　　处：《Cell Research》2013年第12期1420-1423,共4页细胞研究（英文版）

摘　　要：Dear Editor, Lamins are the major components of the nuclear lam ina （NL）, which is located underneath the inner nuclear membrane [1]. Diverse array of functions have been as signed to lamins, and alterations of lamins are associated with a number of human diseases [2]. Of the three lamin genes in mammals, Lmna expresses all isoforms of A type lamins, referred to as lamin-A/C, through alterna tive splicing, while Lmnbl and Lmnb2 express B-type lamins. Despite subtype-specific sequence variations and different expression patterns, lamin proteins exhibit over all sequence similarity. Therefore, a potential functional redundancy among different lamin proteins has made it difficult to precisely address the role of lamins in mam- mals.

关 键 词：核纤层蛋白基因 细胞分化 小鼠胚胎 增殖 哺乳动物 功能多样化 序列相似性 组成部分 

分 类 号：Q959.112.5[生物学—动物学] Q813