成纤维细胞活化在低氧性肺血管重构中的作用  

Role of fibroblasts activation in hypoxic pulmonary vascular remodeling

作　　者：殷广 罗颖[2] 

机构地区：[1]第四军医大学航空航天医学系,陕西西安710032 [2]第四军医大学病理学与病理生理学教研室,陕西西安710032

出　　处：《心脏杂志》2013年第6期716-718,725,共4页Chinese Heart Journal

基　　金：国家自然科学青年基金项目资助(81201516)

摘　　要：以往在低氧性肺血管重构机制的研究中,外膜的作用往往被忽略。新近的研究表明,血管外膜特别是其中的成纤维细胞在调节血管功能中发挥着重要的作用。外膜中的成纤维细胞是低氧刺激的首要"损伤感受细胞",低氧可以激活血管外膜成纤维细胞,活化的成纤维细胞既可以合成分泌细胞生长因子、炎症因子,进而促进中膜血管平滑肌细胞增殖,又可以转分化为平滑肌样细胞(肌纤维母细胞)、分泌胶原蛋白,导致血管重构。因此,低氧导致的成纤维细胞活化及表型转换在肺血管重构中起重要作用,贯穿着低氧性肺血管重构的整个病理过程。Functions of the adventitia were often neglected in previous studies of hypoxic pulmonary vascular remodeling. Recent studies show that vascular adventitia, especially its fibroblasts, plays an important role in vascular function. Adventitia fibroblasts are the primary sensory cells under hypoxic condition and hypoxia can directly activate adventitia fibroblasts. Activated fibroblasts not only synthesize and secrete growth factors and cytokines to promote the proliferation of smooth muscle cells, but also transdifferentiate into smooth musclelike cells （myofibroblasts） and secrete collagen, resulting in vascular remodeling. Therefore, hypoxiainduced fibroblast activation plays a vital role in hypoxic pulmonary vascular remodeling and hypoxic pulmonary hypertension.

关 键 词：低氧 外膜 肺血管重构 成纤维细胞 肌纤维母细胞 

分 类 号：R543.2[医药卫生—心血管疾病]