不同糖耐量绝经后女性胰岛β细胞功能与血浆纤溶酶原激活物抑制剂1和组织型纤溶酶原激活物的相关性  

Beta cell function in relation to plasminogen activator inhibitor-1 and tissue-plasminogen activator in postmenopausal females with different glucose tolerance

作　　者：颜晓芳[1] 严孙杰[1] 杨立勇[1] 刘东晖[1] 张松菁[1] 赵淑好[1] 吴佩文[1] 黄凌宁[1] 易如海[1] 

机构地区：[1]福建医科大学附属第一医院内分泌科,福建福州350005

出　　处：《中华高血压杂志》2013年第11期1045-1048,共4页Chinese Journal of Hypertension

摘　　要：目的探讨不同糖耐量状态下绝经后女性β细胞功能与雌激素、血浆纤溶酶原激活物抑制剂1(PAI-1)及组织型纤溶酶原激活物(t-PA)的关系。方法绝经后妇女123人。糖耐量正常(NGT)38人,糖耐量受损(IGT)51例,2型糖尿病(T2DM)34例。采用ELISA法测定t-PA、PAI-1,放射免疫法测定胰岛素、雌二醇、孕酮、促卵泡刺激素(FSH)、促黄体生成素(LH)。计算稳态模型胰岛素分泌指数(HOMA-B)和胰岛素抵抗指数(HOMA-IR)。结果 T2DM组雌二醇较NGT、IGT组低[(35.46±6.46)比(40.26±1.98)、(37.92±4.95)nmol/L],FSH、LH高于NGT组[(41.66±8.77)比(35.21±7.89)U/L,(32.12±7.76)比(27.46±7.06)U/L,均P<0.05]。T2DM组纤维蛋白原(Fg)、PAI-1高于NGT组,t-PA低于NGT组[(3.97±0.68)比(3.49±0.91)g/L、(49.7±18.9)比(37.2±13.8)μg/L,(10.21±5.21)比(13.98±6.87)μg/L,均P<0.05]。多元逐步线性回归分析显示雌二醇和HOMA-B是血浆PAI-1、t-PA水平的影响因素。结论绝经后女性β细胞功能与纤溶功能低下相关。Objective To investigate the relationship of β cell function with the concentrations of plasminogen activator inhibitor type 1 （PAI-1） and tissue plasminogen activator （t-PA） in postmenopausal females with different glucose tolerance. Methods A total of 123 postmenopausal women were divided into normal glucose tolerance （NGT） group （n=38） , impaired glucose tolerance （IGT） group （n=51） and type 2 diabetic （T2DM） group （n=34）. The plasma concentrations of t-PA and PAI 1 were measured by enzyme-linked immunosorbent assay （ELISA）. The levels of insulin, estradiol （E2）, progesterone （P）, follicle stimulating hormone （FSH） and luteinizing hormone （LH） were determined by radioimmunoassay （RIA）. Homeostasis model assessment-B （HOMA-B） and homeostasis model assessment of insulin resistance （HOMA IR） were calculated. Results The level of E2 was significantly lower inT2DMgroup than inNGTand IGT group [（35.46±6.46） vs （40.26±1.98）, （37.92±4.95）nmol/L], but FSH and LH were higher in T2DM group than in NGT group [FSH （41.66±8.77） vs （35. 21±7.89）U/L; LH （32. 12±7.76） vs （27.46±7.06）U/L, all P〈0.05]. Fibrinogen（Fg） and PAI-1 were higher but t-PA was lower in the T2DM group than in NGT group [（3. 97±0.68） vs （3. 49±0.91） g/L, （49.7±18. 9） vs （37.2±13.8）μg/L, （10.21±5.21） vs （13. 98±6.87）μg/L, respectively; all P%0. 05]. Multiple linear regression analysis showed that E2 and HOMA B were influencing factors of plasma levels of PAI-1 and t-PA in postmenopausal women.Conclusion β cell function is related to the reduced fibrinolytic function in postmenopausal females.

关 键 词：绝经后 血浆纤溶酶原激活物抑制剂 胰岛素分泌 

分 类 号：R541.4[医药卫生—心血管疾病]