Ubiquitin at the crossroad of cell death and survival  

作　　者：Yu-Shan Chen Xiao-Bo Qiu 

机构地区：[1]Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, and College of Life Sciences, Beijing Normal University

出　　处：《Chinese Journal of Cancer》2013年第12期640-647,共8页

基　　金：supported by grants from the Ministry of Science and Technology of China (No.2012CB910300);the National Natural Science Foundation of China (No.30525033);the Fundamental Research Funds for the Central Universities of China to X.-B.Q

摘　　要：Ubiquitination is crucial for cellular processes,such as protein degradation,apoptosis,autophagy,and cell cycle progression.Dysregulation of the ubiquitination network accounts for the development of numerous diseases,including cancer.Thus,targeting ubiquitination is a promising strategy in cancer therapy.Both apoptosis and autophagy are involved in tumorigenesis and response to cancer therapy.Although both are categorized as types of cell death,autophagy is generally considered to have protective functions,including protecting cells from apoptosis under certain cellular stress conditions.This review highlights recent advances in understanding the regulation of apoptosis and autophagy by ubiquitination.Ubiquitination is crucial for cellular processes, such as protein degradation, apoptosis, autophagy, and cell cycle progression. Dysregulation of the ubiquitination network accounts for the development of numerous diseases, including cancer. Thus, targeting ubiquitination is a promising strategy in cancer therapy. Both apoptosis and autophagy are involved in tumorigenesis and response to cancer therapy. Although both are categorized as types of cell death, autophagy is generally considered to have protective functions, including protecting cells from apoptosis under certain cellular stress conditions. This review highlights recent advances in understanding the regulation of apoptosis and autophagy by ubiquitination.

关 键 词：细胞死亡 泛素化 十字路口 细胞凋亡 细胞周期进展 癌症治疗 自噬作用 蛋白降解 

分 类 号：Q255[生物学—细胞生物学]