半月板组织工程研究进展  

Research progress of meniscus tissue engineering

作　　者：陈松[1] 符培亮[1] 丛锐军[1] 吴宇黎[1] 

机构地区：[1]第二军医大学附属上海长征医院关节外科,200003

出　　处：《中国骨与关节杂志》2013年第12期694-698,共5页Chinese Journal of Bone and Joint

基　　金：国家自然科学基金青年科学基金资助项目(81000798)

摘　　要：半月板损伤是关节外科中最常见的损伤之一，半月板的组织工程学修复成为了研究重点。笔者就半月板组织工程涉及的种子细胞、支架材料、细胞因子、机械刺激等最新研究进展作一概述。Objective To review the current research progress of meniscus tissue engineering. Methods Recent literatures concerning meniscus tissue engineering at home and abroad are extensively reviewed, and the current situation and progress are summarized. Results The research of meniscus tissue engineering mainly focuses on the selection of seed cells and their potential of differentiation into chondrocytes, the selection of scaffold materials and their mechanical properties, the mechanisms of action of cytokines in the process of cell culture, the effects of mechanical stimulation on cartilage differentiation and so on. Conclusions Many achievements have been obtained in meniscus tissue engineering. The next study focuses are to find the seed cells more in accordance with the physiological process, easy to culture and with higher chondrogenic differentiation ability, to explore the cytokines that promote seed cells to differentiate into chondrocytes, especially fibrochondrocytes and their mechanisms of action in the process of differentiation, to look for the scaffold materials with strong morphological plasticity, no antigenicity, good degradability, and mechanical properties close to those of the scaffold materials of normal meniscuses.

关 键 词：半月板损伤 组织工程学 关节外科 种子细胞 支架材料 细胞因子 机械刺激 

分 类 号：R318.08[医药卫生—生物医学工程]