杆状病毒-昆虫细胞技术在人用重组蛋白疫苗生产中的应用  

Application of baculovirus-insect cell technique in production of recombinant protein vaccines for human use

作　　者：王伟善[1] 吴浩飞[1] 申硕[1] 杨晓明[1] 

机构地区：[1]武汉生物制品研究所有限责任公司,湖北武汉430060

出　　处：《中国生物制品学杂志》2013年第12期1851-1855,共5页Chinese Journal of Biologicals

摘　　要：杆状病毒-昆虫细胞表达系统是生物领域四大表达系统之一。近年,随着Cervarix誖、Provenge誖和FluBlok誖的批准上市,杆状病毒-昆虫细胞表达系统的发展也取得了里程碑式的重大突破。同时,随着技术的快速发展,杆状病毒-昆虫细胞技术平台在疫苗研发和生产中的应用日益广泛而深入。本文拟对杆状病毒-昆虫细胞技术的起源、发展及其在人用重组蛋白疫苗生产中的应用作一综述。Baculovirus-insect cell expression system is one of four expression systems in biological field. In recent years, with the approval of Cervarix , Provenge and FluBlok , a breakthrough has been gained in the development of baculovirus-insect cell expression system. Meanwhile, with the rapid development of relevant techniques, baculovirus- insect cell technical platform has been widely and deeply used for the development and production of vaccines day by day. This article reviews the source and development of baculovirus-insect cell technology as well as its application in production of recombinant protein vaccine for human use.

关 键 词：杆状病毒科 昆虫细胞 疫苗 重组蛋白质类 

分 类 号：Q782[生物学—分子生物学]