白细胞介素6-634C/G多态性与房颤患者左房血栓和重度左房超声自发显影的关系  

Association of interleukin-6-634C/G polymorphism with left atrial thrombus and severe spontaneous echocontrast in patients with atrial fibrillation

作　　者：石桂良[1] 邓新桃[1] 赵建祥[1] 郑金国[2] 耿海华[2] 潘闽[2] 王如兴[3] 

机构地区：[1]江苏省扬州大学医学院附属兴化市人民医院心内科,江苏兴化225700 [2]南通大学附属医院心内科 [3]无锡市第一人民医院心内科

出　　处：《临床心血管病杂志》2013年第12期907-910,共4页Journal of Clinical Cardiology

基　　金：江苏省"六大人才高峰"项目资助(No:2009046)

摘　　要：目的:研究白细胞介素6(IL-6)-634C/G多态性与心房颤动(房颤)患者左房血栓和重度左房超声自发显影的关系。方法:76例汉族房颤患者进行病例对照研究。经食道超声心动图检查,按是否合并心房血栓分为研究组(31例)与对照组(45例)。采用聚合酶链反应分析房颤患者基因型并检测其基因型频率。结果:研究组IL-6的基因型(CC、CG和GG)频率分别为29.03%、54.54%和16.13%,对照组基因型频率分别为55.56%、40.00%和4.44%,差异有统计学意义(P=0.039 1)。与CC基因型相比,G等位基因携带者(CG+GG)血栓形成或重度左心超声自发性显影的风险增加了2.79倍。结论:IL-6-634C/G多态性与血栓和重度左房超声自发显影相关,G等位基因是汉族房颤患者血栓形成和重度左房自发性显影的独立危险因素。Objective： To investigate the asoeiation of iterleukin-6 -634C/G plymorphism with left atrial thrombus and severe spontaneous echocontrast （SEC） in patients with atrial fibrillation （Af）. Method：We carried out a case-control study in Han Chinese with atrial fibrilliation. The IL-6 -634C/G genotypes of 31 patients with thrombus and 45 patients without thrombus were detected by polymerase chain reaction and restriction fragment length polymorphism. Result： The frequencies of the IL 6 genotypes （CC, CG, and GG） were 29.03%, 54.54%, and 16.13% for the patients with thrombus, and 55.56%, 40.00%, and 4.44% for the patients without thrombus, respectively （P-0. 039 1）. Compared with the CC genotype, the G allele carriers （CG＋GG） had a 2.79-fold increased risk of thrombus or severe SEC. Conclusion： IL-6 -634C/G polymorphism is associated with thrombus and severe SEC, and the G allele is an independent risk for thrombus and severe SEC in Han Chinese patients with Af.

关 键 词：心房颤动 左房血栓 白细胞介素-6 基因多态性 

分 类 号：R541.7[医药卫生—心血管疾病]