局部应用奥曲肽对大鼠背部皮神经跨节段交互兴奋的抑制效应  

Inhibitory effect of octreotide on the cross excitation of adjacent segment of spinal nerve in rat

作　　者：王军[1,2] 曹东元[2,3] 郭媛[2] 马少杰[2] 赵晏[2] 

机构地区：[1]河南大学医学院解剖学教研室,开封475001 [2]西安交通大学生理学与病理生理学系,西安710061 [3]马里兰大学神经和疼痛学系

出　　处：《生理学报》2013年第6期593-599,共7页Acta Physiologica Sinica

摘　　要：本研究在大鼠背部皮下感受野微量注射生长抑素（somatostatin, SST）类似物奥曲肽（octreotide, OCT），观察OCT对大鼠背部皮神经跨节段交互兴奋的作用及可能机制。选取大鼠T9~T13脊神经背侧皮支，游离后进行刺激和记录。逆行电刺激相邻节段神经干，记录单纤维的机械阈值和放电频率。用感受野皮下注射SST类似物OCT或SST受体拮抗剂环生长抑素（cyclo-somatostatin, c-SOM）进行干预，观察交互兴奋特征改变。结果显示：感受野皮下注射OCT可以抑制皮神经交互兴奋引起的放电频率增加和机械阈值降低；c-SOM可以翻转OCT的抑制效应；单纯应用c-SOM可以显著增强交互兴奋现象。以上结果提示，局部应用SST类似物OCT可通过SST受体对大鼠皮神经跨节段的交互兴奋现象产生抑制效应。This study was to observe the effect and possible mechanism of somatostatin analogue octreotide （OCT） on cross excitation of adjacent segment of spinal nerve in rat. Cutaneous branches of T9-T13 spinal dorsal rami were chosen and dissected free for the following recording and stimulation. Only single unit fiber was used for recording, and the adjacent segment of nerve stem was used for antidromic electrical stimulation. TO investigate the change of discharge rate and mechanical threshold, OCT and （or） somatostatin receptor antagonist cyclo-somatostatin （c-SOM） were applied to the receptive field following the antidromic electrical stimulation. The result showed that injection of OCT inhibited the increase of discharge rate and the decrease of mechanical threshold induced by the electrical stimulation （cross excitation）; c-SOM reversed the effects of OCT. Application of c-SOM alone enhanced the cross excitation effects. The results suggest local application of somatostatin analogue OCT can inhibit the cross excitation between the two segments of spinal nerve by somatostatin receptor.

关 键 词：生长抑素受体 脊神经 交互兴奋 

分 类 号：R96[医药卫生—药理学]