慢性低度炎症对多囊卵巢综合征病理生理影响的研究进展  

Advances of effects of chronic low-grade inflammation on pathophysiology of polycystic ovary syndrome

作　　者：林姿均 陶弢[1] 刘伟[1] 

机构地区：[1]上海交通大学医学院附属仁济医院内分泌科,上海200127

出　　处：《上海交通大学学报（医学版）》2013年第12期1667-1672,共6页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(81270875)~~

摘　　要：炎症与代谢综合征的发生和发展密切相关。多囊卵巢综合征(PCOS)是育龄期女性最常见的生殖内分泌代谢性疾病,近年发现PCOS患者存在慢性低度炎症,与其远期并发症的形成密切相关。但最近证据提示慢性持续性炎症出现可能在更早期即参与了PCOS病理生理的发生和发展,如慢性炎症与高雄激素血症、慢性炎症与胰岛素抵抗之间的相互作用。而对PCOS患者慢性低度炎症的早期识别和干预,为PCOS的病因学研究和治疗提供新的思路。Inflammation is closely related to the occurrence and development of metabolic syndrome. Polycystic ovary syndrome （PCOS） is the most common endocrinology metabolic disease in reproductive women. Recent studies showed that PCOS is related to the situation of chronic low-grade inflammation, which is highly correlated to long-term complications of PCOS. However, the new evidences indicated that chronic persistent inflammation may take part in the early development of pathophysiology of PCOS, such as interaction between chronic inflammation and hyperandrogenism and insulin resistence. With the early detection and treatment of chronic low-grade inflammation of PCOS, it can be a new direction of pathogenesis and treatment of PCOS.

关 键 词：多囊卵巢综合征 慢性低度炎症 胰岛素抵抗 高雄激素血症 抗感染治疗 

分 类 号：R711.75[医药卫生—妇产科学]