健康老年人的背侧注意网络:联合独立成分分析与功能连接分析  

Dorsal attention network in healthy elderly:apilot research on independent component analysis combined with correlation analysis

作　　者：齐志刚[1] 邬霞[2] 孙黎[1] 陈楠[1] 李坤成[1] 

机构地区：[1]首都医科大学宣武医院放射科,磁共振成像脑信息学北京市重点实验室,北京100053 [2]北京师范大学信息科学与技术学院,北京100875

出　　处：《放射学实践》2013年第12期1250-1253,共4页Radiologic Practice

基　　金：国家自然科学基金(G81141018;G81271556);北京市科委重点项目(Z101107052210002)

摘　　要：目的:采用fMRI技术初步探讨健康老年人背侧注意网络的构成。方法:使用3.0T MR和8通道头线圈获得25例健康老年人的静息态脑fMRI数据,利用SPM软件对静息态fMRI数据进行预处理,通过独立成分分析获得背侧注意网络的空间构成,并以左侧顶内沟作为种子点进行基于体素的全脑时间序列相关分析,得到与左侧顶内沟呈显著性功能连接脑区的空间分布。结果:背侧注意网络呈现双侧大脑半球的空间分布,主要位于额顶叶区域;通过基于体素的时间序列相关分析,顶内沟与背侧注意网络的大多数组成脑区之间存在功能连接。结论:基于脑fMRI的独立成分分析与基于体素的时间序列相关分析,可提取健康老年人的背侧注意网络,为进一步探索认知损伤患者的注意功能提供指导。Objective：To investigate the composition of dorsal attention network with independent component analysis （ICA） and correlation analysis in healthy elderly. Methods.. Resting-state fMRI examination was performed with 3.0T MR scanner and 8-channel head coil. After pre process of fMRI data,ICA was performed to extract dorsal attention network. Functional connectivity to left intraparietal sulcus was performed in a voxel-wise manner. Results： Dorsal attention network was distributed in bilateral hemispheres, mainly in frontal and parietal lobe. And voxel-wise correlation analysis indicated that left intraparietal sulcus showed functional connectivity to most functional areas of dorsal attention network. Conclusion： Dorsal attention network was extracted through ICA and correlation analysis in healthy elderly,and changes of attention of cognitive impairment patients will be explored in the next step.

关 键 词：健康老年人 磁共振成像 独立成分分析 功能连接 

分 类 号：R445.2[医药卫生—影像医学与核医学] R741.02[医药卫生—诊断学]