伍用利多卡因减少异丙酚注射痛  

LIDOCAINE REDUCES PAIN CAUSED BY PROPOFOL INJECTION

作　　者：赵广翊[1] 申晶 孟凌新 崔健君 

机构地区：[1]沈阳中国医科大学第二临床学院麻醉科,沈阳110003 [2]沈阳中国医科大学第二临床学院手术室,沈阳110003

出　　处：《中国疼痛医学杂志》2000年第4期213-216,共4页Chinese Journal of Pain Medicine

摘　　要：目的 :观察伍用不同剂量的利多卡因对异丙酚注射痛的影响。方法 :2 0 0例女性患者ASAⅠ～Ⅱ级 ,随机分为 4组 ,每组 5 0例。采用双盲法分别静注 1ml 0 .9%盐水、0 .5 %利多卡因 (5mg)、1 %利多卡因 (1 0mg)、2 %利多卡因 (2 0mg)与 1 9ml 1 %异丙酚混合液 ,观察各组异丙酚注射痛的发生情况。结果 :利多卡因明显减小了异丙酚静注即刻和麻醉苏醒后回忆的疼痛发生率及严重程度 ,利多卡因剂量与异丙酚静注疼痛的发生率及严重程度呈负相关 (二者均P <0 .0 0 1 )。结论 :伍用利多卡因2 0mg明显减少异丙酚注射痛的发生率及严重程度。Aim: To observe whether concomitant administration of lidocaine could reduce pain induced by propofol injection. Methods: In a randomized double blind trial, 200 women of ASA status 1 or 2 were allocated to one of four groups to receive 19ml of propofol mixed with either 1ml of 0.9% saline, 1ml of 0.5%(5mg) lidocaine ,1ml of 1%(10mg) lidocaine or 1ml of 2%(20mg) lidocaine. The pain of injection was recorded. Results: Lidocaine reduces the incidence and severity of pain caused by propofol injection, both during induction of anesthesia and as recalled after the surgical operation. A highly significant negative dose response relationship was observed between the dose of lidocaine and the severity of pain ( P <0.001). Conclusion: Lidocaine 20mg premixed with propofol significantly reduces the incidence and severity of pain produced by propofol injection.

关 键 词：异丙酚 利用卡因 注射性疼痛 配伍 副作用 

分 类 号：R614[医药卫生—麻醉学]