几种胶原酶抑制剂滴眼液的效果比较  

Comparative study on the effects of collagenase inhibitor in different eye drops

作　　者：沈远萍[1] 张泺[1] 胡正[1] 

机构地区：[1]同济医科大学附属同济医院眼科,湖北省武汉市430030

出　　处：《眼科新进展》2000年第6期426-427,共2页Recent Advances in Ophthalmology

摘　　要：目的　观察比较 6种眼科外用药物 ,为临床筛选较强的抑制胶原酶的眼液。方法用鼠胶原、胶原酶及考马斯亮蓝比色法来检测药物抑制胶原酶的能力。结果　 6种药物有不同程度抑制胶原酶作用 ,其中卡托普利极强、乙酰半胱氨酸和依地酸钠较强 ,而枸橼酸钠、硫代硫酸钠和四环素较差。结论　 0 .5 g· L- 1卡托普利眼液抑制胶原酶能力极强、副作用小、刺激性极微。Objective To investigate, compare and filtrate the collagenase inhibitor effects among six kinds of eye drops for clinical use.Methods The collagenase inhibitor’s effects were detected by rat's collagen and collagenase with comassie brilliant blue colorimetric method.Results The inhibitting collagenase effects among six kinds of eye drops were different: the effect of cartopril was the strongest;the acetylcysteine and sodium edetate were more strong and the sodium citrate, sodium hyposulfite and tetracycline were less strong.Conclusion 0.5g·L -1 cartopril eye drops has stronger efficacy to inhibit collagenase, with less side effect or stimulation,more convenient resource and preparation than other eye drops.

关 键 词：胶原酶抑制剂 滴眼剂 考马斯亮蓝比色法 

分 类 号：R988.1[医药卫生—药品]