美心力与硝酸甘油联用治疗充血性心力衰竭的临床观察  

Clinical investigation of the effects of cAMP and nitroglycerin in severe congestive heart failure

作　　者：荆文庆[1] 马玉芳[1] 郭牧[1] 曹袁宁[1] 

机构地区：[1]宁夏银川市第一人民医院心内科,宁夏银川750001

出　　处：《宁夏医学杂志》2000年第12期727-728,共2页Ningxia Medical Journal

摘　　要：目的　探讨美心力对充血性心力衰竭 (CHF)患者的治疗效果。方法　选择CHF心功能Ⅲ～Ⅳ级住院患者 6 0例。随机分为治疗组 30例 ,采用美心力和硝酸甘油联用 ;对照组 30例 ,单用硝酸甘油。比较治疗前后两组的临床症状、体征和心功能分级、心功能指标 ,并观察疗效和记录有无副作用。结果　治疗组临床总有效率 83 3% ,对照组总有效率 76 6 % (P <0 0 5 )。心功能测定 ,治疗组治疗前后比较各项指标改善均有显著性差异 (P <0 0 1) ,对照组收缩功能改善有显著性差异 (P <0 0 1) ,舒张功能无改善 (P >0 0 5 )。治疗组与对照组比较 ,收缩功能改善无差异 (P >0 0 5 ) ,而舒张功能改善有显著差异 (P <0 0 1)。治疗组在用药过程中未见毒副作用。结论　美心力是治疗CHF患者安全有效的药物 。Objectives ToevaluatethetherapeuticeffectofcAMPonpatientswithcongestiveheartfailure(CHF) .Methods 60patientswithCHF (NYHAclassⅢ～Ⅳ )weretreatedinhospital,andweredividedintotwogroups ,cAMPgroup(n =30 )weretreatedwithcAMPandnitroghycerin ,controlgroup (n =30 )weretreatedonlywithnitroglycerin .Beforeandafterthetreatment,clinicalsymptoms ,singns,cardiacfunctionalclassesandinotropicindicesofboth groupswereinvestigated ,theside -effectswerealsoobservedandrecorded .Results TotaleffectiverateofthecAMPgroupwas83 .3 %andthecontrolgroup was 76 .6 % (P <0 .0 5) .Afterthetreatment,cardiacfunctionincreasedremarkabalycomparedwithbeforeinthecAMPgroup(P <0 .0 1 ) ,thesystolicfunction increasedremarkabalyinthecontrolgroup(P <0 .0 1 ) ,thediastolicfunctionwerenotchanged(P >0 .0 5) .Aftertreament,comparedwiththecontrolgroup , thesystolicfunctionnotincreasedremarkabaly(P >0 .0 5) ,thediastolicfunctionincreasedremarkabalyinthecAMPgroup(P <0 .0 1 ) .Therewerenosignifi cantside -effectsobservedinthecAMPgroup .Conclusions cAMPwasasafe,effectivedrugforthepatientswithCHF ,couldbeoneoftheeffectivedrugto treatCHF .

关 键 词：充血性心力衰竭 美心力 

分 类 号：R541.610.5[医药卫生—心血管疾病]