临床输液中混浊沉淀和药液变色的现象分析  

Analysis of Phenomenon of Turbid Precipitation and Discoloration in Clinical Infusions

作　　者：樊国斌 李素娟 沈钦华 

机构地区：[1]武汉市东西湖区人民医院,武汉430040

出　　处：《抗感染药学》2013年第4期289-292,共4页Anti-infection Pharmacy

摘　　要：目的:分析临床输液中混浊沉淀和药液变色的原因,规范临床合理用药。方法:对临床反馈的几例在使用中出现混浊、变色的现象进行综合分析。结果:头孢唑啉和头孢匹胺宜选用0.9%氯化钠注射液为溶媒;头孢菌素类药物与喹诺酮类药物联用中间宜采用冲管或静滴其他药物;甘露醇注射液中禁加其他药物;头孢拉定和奥美拉唑不宜与酸性药物配伍或联用;头孢菌素类药物与奥硝唑-氯化钠注射液联用易发生变色。结论:应加强注射药物合理使用和规范配制的宣传,保障临床安全用药。Objective： To analyze the reasons why turbid precipitates and discoloration appears during the process of mutual compatibility of drug use and to standardize the clinical use of drugs. Methods： Analysis of several clinical feedback cases, in which turbid precipitates and infusion discoloration appears. Results： The 0.9% sodium chloride injection should be selected as the solvent for the cefazolin and cefpiramide. and 0.9% sodium chloride injection or other drugs should be intravenous dripped between the cephalosporin and quinolones drugs. Other drugs are prohibited to add into the mannitol injection. The cephradine and omeprazole should not be combined with acidic drugs. The discoloration might easily appear when the cephalosporin drugs are combined with ornidazole sodium chloride injection. Conclusion： In order to ensure medication safety, the publicity about rational use of injection and specifical preparation should be strengthened.

关 键 词：混浊 沉淀 药液变色 合理用药 分析 

分 类 号：R969.3[医药卫生—药理学]