儿童IgA肾病与过敏紫癜性肾炎的临床和病理对照研究  

Clinical and pathologic comparison study of children IgA nephropathy and henoch-schonlein purpura nephritis

作　　者：张自宜 彭君娥 

机构地区：[1]湖南旺旺医院儿科,湖南长沙410016

出　　处：《中国现代医生》2013年第35期150-151,154,共3页China Modern Doctor

摘　　要：目的 比较儿童IgA肾病与过敏紫癜性肾炎的临床和病理特征,为临床诊治提供参考. 方法选择本院2010年1月～2012年12月收治的经临床确诊的儿童IgA肾病患儿40例,过敏性紫癜性肾炎患儿40例,分析两组患儿一般临床资料及病理特征,并进行组间比较.结果 （1）临床特征：两组发病性别差异无显著性（P〉0.05）;发病年龄方面,IgA肾病组12岁以上患儿所占比例更高（P〈0.05）;发病季节方面,紫癜性肾炎组患儿秋季发病所占比例明显高于IgA肾病组（P〈0.05）;紫癜性肾炎组胃肠症状、关节痛、紫癜性等合并症状明显多于IgA肾病组（P〈0.05）.（2）病理特征：过敏性紫癜组球性硬化、系膜硬化发生率明显少于IgA肾病组（P〈0.05）,内皮增生明显多于IgA肾病组（P〈0.05）,两组沉积物类型差异显著（P〈0.05）. 结论儿童IgA肾病与过敏紫癜性肾炎虽然有相似的免疫异常,但临床、病理特征情况均有明显差异,提示临床应注意区别对待.Objective To compare the clinical and pathologic characteristic of children IgA nephropathy and henochschonlein purpura nephritis, in order to provide reference for clinical diagnosis and treatment. Methods About 40 cas- es of children with IgA nephropathy, and 40 cases with henoch-schonlein purpura nephritis in our hospital from Jan- uary 2010 to December 2012 were selected, and clinical and pathological characteristic of two groups were analyzed and compared. Results （1） Clinical characteristics： the gender of two groups was not significantly different （P〉0.05）, in IgA nephropathy group, the proportion of children aged above 12 years old was higher （P〈0.05）. In incidence season, autumn incidence of henoch-schonlein purpura nephritis group was significantly higher than IgA nephropathy group （P〈0.05）. In gastrointestinal symptoms, joint pain, purpura and other symptoms of nephritis group of was significantly more than IgA nephropathy group （P〈0.05）. （2） Pathological features： in hcnoch-schonlein purpura nephritis group, the incidence of global sclerosis, mesangial sclerosis was significantly lower than IgA nephropathy group （P〈0.05）, prolif eration of endothelial was significantly more than IgA nephropathy group （P〈0.05）, sediment types of two was signifi cantly different （P〈0.05）. Conclusion Children IgA nephropathy and henoch-schonlein purpura nephritis although have similar immune abnormalities,but clinical pathological features is significantly different, suggesting that clinical attention should be paid differently.

关 键 词：儿童IGA肾病 过敏性紫癜性肾炎 临床特征 病理特征 

分 类 号：R726.9[医药卫生—儿科]