猕猴桃根多糖多相脂质体口服液对CCl_4所致实验性急性肝损伤的药效作用  

Effects of Actinidia Planch Polysaccharide Polyphase Liposome Oral Liquid on Experimental Acute Liver Injury Mice Induced by CCl_4

作　　者：朱雨晴[1,2] 石森林[1] 吴瑾瑾[1] 李昌煜[1] 葛卫红[1] 戴文芸[1] 

机构地区：[1]浙江中医药大学药学院,浙江杭州310053 [2]富阳妇幼保健院药剂科,浙江富阳311400

出　　处：《中华中医药学刊》2013年第12期2665-2667,I0020,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省自然科学基金资助项目(Y2101417);浙江省中医药科技计划资助项目(2007CA114)

摘　　要：目的:评价猕猴桃根多糖脂质体口服液的抗急性肝损伤作用。方法:采用CCl4所致小鼠急性肝损伤模型,以联苯双酯作为阳性对照药,通过测定肝损伤小鼠的血清中谷丙转氨酶(ALT)、谷草转氨酶(AST)、测定肝损伤小鼠肝脏中的超氧化物歧化酶(SOD)、丙二醛(MDA)等指标,观察肝组织病理改变,研究APPS多相脂质体口服液的抗急性肝损伤药效作用;结果:与模型组比较,APPS多相脂质体口服液高剂量(200 mg·kg-1)、中剂量(100 mg·kg-1)可显著降低血清中ALT、AST含量(P<0.05),有效提高肝组织SOD活力、降低MDA含量(P<0.05),与联苯双酯的药效作用无统计学差异。结论:APPS多相脂质体口服液对CCl4所致小鼠急性肝损伤有显著的保护作用。Objective： To evaluate the pharmaeodynamic actions of Aetinidia Plancli polysaccharide（APPS） polyphase liposome oral liquid on CC14 - induced acute liver injury mice. Methods ： The mice model of acute liver injury induced by CC14 was adopted, taking bifendate as a positive control drug, by determinations of ALT and AST in serum of the liver - injured mice and measuring the indicators in mice liver, such as SOD, MDA, and so on, the test observed the pathologi- cal changes of the liver tissue, studied the function of pharmacodynamics with APPS polyphase liposome oral liquid in a- gainst acute liver injury. Results： Compared with the group of model, the high dosage （200mg · kg^-2 ） and middle dos- age （100mg · kg^-1） of APPS polyphase liposome oral liquid reduced the contents of ALT and AST significantly （P 〈 0.05） in serum. And the oral liquid improved the vitality of SOD effectively in liver tissue and reduced the content of MDA（P 〈0.05）. There was no difference in statistics between the result and the hepatoprotective effect of pharmacody- namics with bifendate. Conclusion： The APPS polyphase liposome oral liquid has a significant and protective effect in mice suffering from CC14 - induced acute liver injury.

关 键 词：APPS脂质体 CCl4所致肝损伤 药效作用 

分 类 号：R285.5[医药卫生—中药学]