重型再生障碍性贫血患者不同中医分期耐缺氧相关指标差异性研究  

Hypoxia Tolerance Indicators Differences in TCM Periods of Patients with Severe Aplastic Anemia

作　　者：庄海峰[1] 魏丽萍[1] 陈美玲[1] 杨飞[1] 胡通林[1] 吴迪炯[1] 沈建平[1] 

机构地区：[1]浙江中医药大学第一附属医院,浙江杭州310053

出　　处：《中华中医药学刊》2013年第12期2682-2684,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省中医药科技重大疾病平台资助项目(2009ZDJB01-04)

摘　　要：目的:通过对19例重型再生障碍性贫血(serious anemia aplastic,SAA)患者相关耐缺氧指标(促红细胞生成素EPO、ATP酶、低氧诱导因子)进行研究,旨在明确症状的改善是否与提高患者缺氧耐受力有关,并明确在此之前患者是否在不同阶段就存在着耐缺氧能力的差异,因而才导致其对药物治疗的敏感性不同。方法:通过对19例SAA患者凉-温-热的分期,予以中西医结合的治疗,观察治疗不同阶段,促红细胞生成素EPO、ATP酶、低氧诱导因子3个耐缺氧指标的前后变化,筛选指导临床用药的有效指标。结果:促红细胞生成素EPO是可以较好反应不同治疗阶段患者耐缺氧能力的指标因子。结论:通过测定促红细胞生成素EPO,评估患者不同治疗阶段的耐缺氧能力,加上患者的自觉症状,可以从另一个角度评估治疗效果。Objective： In this study, related hypoxia tolerance indicators （erythropoietin prime the EPO , ATP en- zyme, hypoxia inducible factor） of 19 patients with severe regenerative anemia （serious anemia aplastic, SAA） were studied to clarify whether symptoms improvement is related to improved patients hypoxia tolerance and to clear whether patients in different stages had the existence of hypoxic tolerance, which led to their sensitivity to medication. Method： Through giving combination treatment of Chinese and Western medicine of cold, warm and heat staging of 19 SAA pa- tients, observation on EPO, ATP enzyme, hypoxia - inducible factor was carried on before and after changes for screening effective indicators of clinical treatment. Results ： EPO index factor was screened and had better reaction of hypoxic toler- ance of patients with different stages of treatment. Conclusion ： Determination of EPO can assess hypoxic tolerance of pa- tients with different stages of treatment, coupled with the symptoms of the patients, from another angle, to assess the ther- apeutic effect.

关 键 词：再生障碍性贫血 耐缺氧 

分 类 号：R556.5[医药卫生—血液循环系统疾病]