参麦注射液在心肌缺血患者体内的群体药动学研究  

Population Pharmacokinetics of Shenmai Injection in Patients with Myocardial Ischemia

作　　者：王清[1] 朱萱萱[1] 周杰[2] 马国平[1] 

机构地区：[1]南京中医药大学附属医院,江苏南京210029 [2]南京中医药大学,江苏南京210029

出　　处：《中华中医药学刊》2013年第12期2702-2705,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：江苏省高校优势学科建设资助项目(P200962)

摘　　要：目的:建立参麦注射液在心肌缺血患者体内的群体药动学模型,为临床个体化给药提供参考。方法:用非线性混合效应模型(NONMEM)建立参麦注射液的临床群体药动学模型,考察人口统计学指标、生理生化指标等相关因素对群体药动学参数的影响,并进行模型验证。结果:以二房室模型为基础药动学模型进行拟合,群体药动学参数θCL、θVc、θQ、θVp分别为(0.011±0.0003)L·h-1,(0.1±0.007)L,(0.016±0.006)L·h-1,(0.362±0.159)L。结论:用NONMEM软件拟合建立了的参麦注射液的群体药动学模型,经验证稳定可靠,可以用于参麦注射液的临床药代动力学研究。Objective ：To construct the population pharmacokinetic model of Shenmai Injection （SMI） in patients with myocardial ischemia for individualized drug therapy in clinical practice. Method：NONMEM was employed to establish the population PK model of SMI. The effects of demography and biochemical covariates were investigated. Internal and exter- nal validations were conducted for the model. Result ： A two - compartment model was confirmed as structure model of SMI, the population typical values of θcf., θvo, θQ, θvp were （0.011 ±0. 0003 ） L· h^-1, （ 0. 1 ±0. 007 ） L, （0. 016 ±0. 006）L · h^-1, （0.362 ±0. 159 ）L. Conclusion：The final PPK model of SMI in patients with myocardial ischemia was established by NONMEM. The PPK model was steady and reliable.

关 键 词：参麦注射液 群体药动学 非线性混合效应模型 

分 类 号：R542.2[医药卫生—心血管疾病]