榄香烯缓释片的研制及体外释放度考察  

Preparation of Elemene Sustained-Release Tablets and Its Drug Release in Vitro

作　　者：范海珠[1] 刘艳莉[1] 谢恬[2] 

机构地区：[1]浙江省中医院,浙江杭州310006 [2]杭州师范大学,浙江杭州310012

出　　处：《中华中医药学刊》2013年第12期2799-2801,共3页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的:制备榄香烯缓释片剂,并评价其释放特性。方法:用正交试验设计对片剂的处方、工艺进行筛选与优化,制备榄香烯缓释片剂,测定其释放特性。结果:正交设计获最优处方为A3B2C2,即亲水凝胶骨架材料为HPMC(K4M),用量为5%,微晶纤维素与乳糖的比例为2∶1。药物体外释放行为符合Higuich方程。结论:该方法制得的缓释片具有良好的缓释效果,且制备工艺简单易行。Objective： To prepare sustained - release elemene tablet and evaluate its drug release property. Methods ： The optimal formulation and technology of the tablet were found with orthogonal experiment design. Results ： The optimized prescription was A3B2C2：HPMC （K4M） as hydrophilic gel matrices material; 5% dosage; 2 ： 1 MCC and lactose. The release of elemene sustained- release tablets in vitro fitted the Hignich equation. Conclusion：The tablets have desirable sustain -release capability. The formulation and technique are simple and can be applicable in production.

关 键 词：榄香烯 缓释 制备工艺 释放度 

分 类 号：R284.3[医药卫生—中药学]