迁延性腹泻患儿血尿锌水平的变化及对其补锌的临床效果评价  

Hematuria zinc level change in children with persistent diarrhea and the clinical efficacy evaluation of zinc supplementation

作　　者：曹哲连 

机构地区：[1]张家界慈利县人民医院儿科,湖南慈利427200

出　　处：《中国当代医药》2013年第32期16-17,19,共3页China Modern Medicine

摘　　要：目的 探讨迁延性腹泻患儿血尿锌水平的变化及对其补锌的临床效果.方法 收集2008年3月～2013年3月入住本院的100例迁延性腹泻患儿及同期于本院保健科体检的健康儿童50例的尿及末梢血,采用多通道原子吸收光谱法对血、尿锌水平进行检测、分析.将患儿组按照抽签方法随机均分为非补锌组与补锌组,两组均给予补充水电解质、纠正酸中毒、微生态疗法以及支持疗法等常规治疗,补锌组在此基础上口服赖氨葡锌颗粒.比较患儿组与健康对照组血、尿锌水平,补锌组与非补锌组患儿的治疗效果、止泻时间及平均住院时间.结果 患儿组血锌、尿锌及尿锌/尿肌酐水平均明显低于健康对照组（P＜0.05）;非补锌组临床治疗总有效率为64.00％,补锌组临床治疗总有效率为92.00％,两组差异有统计学意义（P＜0.01）;补锌组止泻时间与平均住院时间分别为（4.52±1.27）d与（7.59±2.69）d,非补锌组分别为（6.99±2.01）d与（11.71±3.38）d,两组比较,差异有统计学意义（P＜0.01）.结论 迁延性腹泻患儿血尿锌水平较健康儿童显著降低,应及时给予补锌治疗.Objective To analyze the hematuria zinc level change in children with persistent diarrhea and to evaluate the clinical efficacy of zinc supplementation.Methods 100 patients with persistent diarrhea treated in our hospital from March 2008 to March 2013 and 50 healthy children from health examination in our Health Division over the same pe- riod were collected and then detected and analyzed their zinc levels by multi-channel atomic absorption spectrometry. Patients were equally and randomly divided into zinc group and non-zinc group by lot.The two groups were given wa- ter and electrolyte supplement,corrected acidosis,microbial therapy and supportive therapy and other conventional treatment.Patients in zinc group were added with oral lysine and zinc glueonate granules.Comparisons of blood and urine zinc levels between the patient＇s group and the healthy control group and the treatment effects,diarrhea-stopping time and average length of stay between the zinc and non-zinc group were made.Results The patients group had sig- nificantly lower blood Zn,urinary Zn and urinary Zn/Cr level than that of the healthy control group respectively （P〈0.05）;non-zine group＇s clinical total effective rate was 64.00%,zinc group＇s clinical total effective rate was 92.00%, there was significant difference （P〈0.01）;zinc group＇s diarrhea-stopping time and the average hospital stay was （4.52± 1.27） d and （7.59±2.69） d,while the non-zinc group＇s was （6.99±2.01） d and （11.71±3.38） d,there was significant dif- ference （P〈0.01）.Conclusion Children with persistent diarrhea have significantly lower zinc level in blood and urine than healthy children.Zinc complement should be given to them in a timely manner.

关 键 词：迁延性腹泻 血尿锌 补锌 临床效果 

分 类 号：R725.7[医药卫生—儿科]