利多卡因用于预防丙泊酚静脉注射痛的最佳浓度  

The best concentration of lidocaine for prevention of injection pain caused by propofol

作　　者：姜世良 

机构地区：[1]山西省怀仁县人民医院,山西怀仁038300

出　　处：《中国当代医药》2013年第36期93-94,共2页China Modern Medicine

摘　　要：目的观察不同剂量的利多卡因用于预防丙泊酚静脉注射痛的效果。方法选择200例人工流产患者，随机分成4组，L0组1％丙泊酚液中不加利多卡因、L1组总量为10ml的1％丙泊酚与利多卡因混合液中加2％利多卡因1ml、L2组总量为10ml的1％丙泊酚与利多卡因混合液中加2％利多卡因1．25ml、L组总量为10ml的1％丙泊酚与利多卡因混合液中加2％利多卡因1．5ml，每组各50例。所有患者均先静脉输注芬太尼1．0μg／kg后，再缓慢经脉注射1％丙泊酚或丙泊酚与利多卡因混合液，含丙泊酚1～2mg／kg。观察记录各组发生注射痛的情况。结果I_0组患者的静脉注射痛发生率最高，L1组仍有轻微静脉注射痛发生，L2组和L3组比较差异无统计学意义，基本消除了丙泊酚静脉注射痛。结论总量为10ml的1％丙泊酚与利多卡因混合液中加2％利多卡因1．25ml，即混合液中利多卡因的浓度为0．25％，是预防丙泊酚注射痛的最低满意浓度，即最佳浓度。Objective To observe the effect of different dosage of lidocaine for prevention of injection pain caused by propofol. Methods 200 cases of abortion were divided into four groups randomly,the L0 group was given propofol without lidocaine,the L1 group was given 10 ml of 1% propofol with 1 ml of 2% lidocaine,the L2 group was given 10 ml of 1% propofol with 1.25 ml of 2% lidocaine,the L3 group was given 10 ml of 1% propofol with 1.5 ml of 2% lidocaine, each group had 50 cases.All these patients were given the intravenous fentanyl （1.0 μg/kg） before intravenous propofol with or without lidocaine （propofol 1-2 mg/kg）.The situations of injection pain in each group were observed. Results The incidence of injection pain was highest in the L0 group.Patients in the L1 group still had minor injection pain.The injection pain in the L1 and L2 group was almost disappeared and had no significant difference. Conclusion The mixture of 10 ml of 1% propofol with 1.25 ml of 2% lidocaine （0.25% lidocaine in the mixture） is the best concentration for prevention of injection pain.

关 键 词：静脉注射痛 丙泊酚 利多卡因 

分 类 号：R614[医药卫生—麻醉学]