药用NO在金属有机骨架材料中的储存和缓释  

Metal-Organic Frameworks as Host Materials for Storage and Slow-Releasing of Medicinal Nitric Oxide

作　　者：薛春峰[1] 徐婷婷[1] 

机构地区：[1]太原理工大学化学化工学院精细化工研究所,太原030024

出　　处：《化学通报》2013年第12期1086-1090,共5页Chemistry

基　　金：太原理工大学创新研究项目(TYUT-CR201113A)资助

摘　　要：多孔金属有机骨架化合物具有发达的纳米级孔道,其对生物活性气体一氧化氮(NO)的储存和缓释显示出独特的物理与化学性质。目前,基本采用两种方式储存NO,一是通过与材料中的不饱和金属络合,另一是与材料中的氨基形成N-Diazeniumdiolate结构,两种方式储存的NO均可通过水置换反应释放,其缓释动力学受材料的化学组成、孔结构和NO的结合强度影响。本文主要综述了近年来金属有机骨架材料储存和释放NO的研究进展。Porous metal-organic frameworks （ MOFs ） with developed nanochannels exhibit unique physicochmnical features in gases sorption. Their storage and slow-releasing properties for medicinal nitric oxide provoked more and more attractions. At present, two ways were mainly used for NO storage. NO coordinated with unsaturated metals in MOFs and/or formed diazeniumdiolate structures with amino groups located in materials. The stored NO could be released by triggering with water. MOFs containing unsaturated metals performed better properties of NO storage and slow-releasing than amino group functionalized MOFs. However, the former was rare and lack of enough unsaturated metals. The later was abundant but its performance for NO storage was poor. The storage amount of NO can be enhanced by increasing unsaturated metal sites in MOFs and combining their advantages with functional groups. The dynamic of slow-releasing was relevant to the composition, pore structure and bonding strength with NO of the materials. Problems including stabilities of MOFs, toxicity of metals, and targeted releasing should be well resolved. The challenges for an ideal NO carrier eneompass not only the developments of solids with good bio- compatibility and without cell metabolism hut also the storage amount and slow self-releasing of medicinal NO to fit proposed applieations.

关 键 词：金属有机骨架化合物 一氧化氮 储存 缓释 

分 类 号：TB383.4[一般工业技术—材料科学与工程]