复方紫柄冬青软膏的再评价  

Re-evaluation of the compound Zibingdongqing cream

作　　者：胡晓波[1] 谭蓉[1] 涂金兰[1] 尹航[1] 

机构地区：[1]贵阳医学院附属医院,贵州贵阳550002

出　　处：《中国医院药学杂志》2013年第24期2042-2045,共4页Chinese Journal of Hospital Pharmacy

基　　金：贵州省科学技术基金项目[编号:黔科合J字(2012)2032号]

摘　　要：目的:医院传统经验方剂复方紫柄冬青软膏的再评价。方法:回顾性分析该软膏的起源及临床应用范围;对处方药材进行生药学鉴定;以金黄色葡萄球菌、大肠埃希菌、铜绿假单胞菌等3种致病菌株为实验菌株,对软膏进行体外抗菌作用考察。结果:生药学鉴定紫柄冬青为冬青科冬青属植物四季青(Ilex chinensis folium);银花为忍冬科山银花(Lonicerae flos);含药0.015 62,0.062 5和0.125 g·mL-1复方紫柄冬青软膏样品溶液分别对大肠埃希菌;铜绿假单胞菌和大肠埃希菌;金黄色葡萄球菌、铜绿假单胞菌及大肠埃希菌有抑制作用。结论:体外抗菌考察结果从现代药理学角度,解释了此传统医院经验方剂用于烧伤、烫伤、感染性伤口及促进溃疡面愈合等具有一定临床疗效的结论。OBJECTIVE To reevaluate the compound Zibingdongqing cream, a hospital preparation. METHODS A retrospective analysis of the origin and clinical applications of the cream was made, and the pharmacognosy of prescription medicines was identified. The anti-bacterial effects of compound Zibingdongqing cream in vitro against Staphylococcus aureus, Escherich- ia toll, and Pseudomonas aeruginosa were investigated. RESULTS The results of pharmacognosy identification showed that Zibingdongqing was Ilex chinensis folium, and honeysuckle was Flos Lonicerae Confusae. Different concentrations of compound Zibingdongqing solution （0. 015 62,0. 062 5,0. 125 g.mL-1） all showed anti bacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomumas aeruginosa in the in vitro studies. CONCLUSION The anti-bacterial testing in vitro ex plains that the hospital traditional prescription compound Zibingdongqing cream may have some effects on burn, scald, wound infection, and promote the ulcer to heal up.

关 键 词：紫柄冬青 软膏 生药学 体外抗菌实验 

分 类 号：R289.5[医药卫生—方剂学]