心血管植入生物材料表面生物化修饰研究进展  

Research progress on surface biomodification of cardiovascular implanted biomaterials

作　　者：李贵才[1,2,3] 杨苹[2] 黄楠[2] 

机构地区：[1]南通大学江苏省神经再生重点实验室,江苏南通226001 [2]西南交通大学材料先进技术教育部重点实验室,四川成都610031 [3]淮阴工学院江苏省介入医疗器械重点实验室,江苏淮安223003

出　　处：《功能材料》2013年第24期3520-3525,3533,共7页Journal of Functional Materials

基　　金：国家重点基础研究发展计划(973计划)资助项目(2011CB606204);国家自然科学基金资助项目(30870629;51175212);江苏省介入医疗器械重点实验室开放课题资助项目(JR1205)

摘　　要：表面修饰是生物医学材料领域的核心技术之一,其根本目的就是要使生物材料表面具有更好的生物相容性。目前,人们已经开发出了多种生物材料表面修饰的方法。根据生物材料应用领域的不同以及面临问题的差异,其所采取的表面修饰方法也各有区别,或减少蛋白吸附和凝血,或控制细胞粘附、生长和分化,或改善材料的力学性能等。心血管生物材料领域的表面修饰技术主要针对提高材料的血液相容性和内皮细胞相容性等方面,进一步可以拓展到组织工程和再生医学方面。就心血管植入生物材料的研究现状、表面生物化修饰方法以及针对不同目的的表面改性技术进展进行了综述,以期能够为设计和开发新一代心血管植入医疗装置提供重要的参考。Surface modification was one of the core technologies in the field of biomedical materials,its funda-mental purpose was to make the surface of the biological material has better biocompatibility.Presently,vari-ous surface modification has been developed by different groups,and different methods of surface modification was selected in terms of the application fields and the faced problems of biomaterials,including reducing protein adsorption and coagulation,controlling cell adhesion,growth and differentiation,and improving the mechanical properties.The surface modification technology of cardiovascular biomaterials mainly focus on improving the blood compatibility of the materials and the endothelial cell compatibility,and can be further expanded to tissue engineering and regenerative medicine.In this paper,the research status of cardiovascular biomaterials,the surface biomodification methods and the surface modification technology for different purposes are reviewed,in order to provide important reference for the design and development of a new generation of cardiovascular im-plantable medical devices.

关 键 词：心血管植入生物材料 表面修饰 血液相容性 内皮化 复合功能 

分 类 号：TB324[一般工业技术—材料科学与工程] TB318.08