肿瘤治疗用Fe_3O_4/P(NIPAAm-co-Am)磁性聚合物复合微球的磁热性能  

Magnetocaloric effect of Fe_3O_4/P(NIPAAm-co-Am)composite microspheres for tumor treatment application

作　　者：范少勇[1,2] 黄科棣[2] 唐清美[2] 黄志荣[2] 艾凡荣[1] 陈伟高[1] 

机构地区：[1]南昌大学机电学院,江西南昌330031 [2]南昌市洪都中医院,江西南昌330006

出　　处：《功能材料》2013年第B12期273-276,共4页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(51102131)

摘　　要：利用磁性纳米粒子在交变磁场作用下的磁热效应,来实现对Fe3O4/P(NIPAAm-co-Am)复合微球温度的控制,以达到肿瘤热疗与化疗联合治疗的目的。主要研究了交变磁场作用下复合微球的磁热性能的影响因素。研究结果表明,所制备的Fe3O4/P(NIPAAm-co-Am)复合微球具有很好的超顺磁性,且在交变磁场作用下具有很好的磁热效应,其磁热效应可以通过调节微球的浓度、交变磁场的磁场强度和频率等因素来调控,以适应不同应用场合需求。Research on the magnetic thermo-sensitive composite microspheres for controlled release drug carrier was meaningful. Magnetocaloric effect was used to heat the Fe304/P （NIPAAm-co-Am） composite micro spheres, and the heat generation abilities of the composited microspheres in alternation magnetic field （AMF） were investigated in the present work. Results show the resultant Fea04/P（NIPAAm-co-Am） composite mi- crospheres exhibite excellent superparamagnetic and high heating generation ability. The temperature of the composite microspheres was raised after exposed to AMF, which can stimulate the shrinks of P（NIPAAm-co- Am）. Furthermore, the temperature raised after exposed to AMF can be adjusted by controlling the concentra tion of composite microspheres, the magnetic intensity and the freauencv of the AMF

关 键 词：肿瘤磁热疗 化疗 磁热效应 温敏性聚合物 药物控释 

分 类 号：O614.8[理学—无机化学]