热对胞必佳的理化性质和生物活性的影响  

The Effect of Heat on Physicochemical Properties and Bioactivities of Bao Bi Jia

作　　者：张祝兰[1] 林善[1] 唐文力[1] 洪金基[1] 

机构地区：[1]国家医药管理局,福建省微生物研究所福州350007

出　　处：《海峡药学》2000年第4期94-96,共3页Strait Pharmaceutical Journal

摘　　要：探讨热对胞必佳的理化性质和生物活性的影响 ,将胞必佳分别加热至 12 1℃ 15 min～ 15 0 min,130℃、140℃、15 0℃、16 0℃、170℃各 15 min。结果 ,加热 12 1℃ 15 0 min以内或不高于 15 0℃ 15 min的各试验组与未加热样品比较 ,其外观性状、溶解性、p H值、N— CWS含量均无明显变化 ,对小鼠 S180抑瘤率均在 5 0 %以上。结果表明胞必佳能耐受 12 1℃ 15 0 min或15 0℃ 15 min。The influence of heat on physicochemical properties and bioactivities of Bao Bi Jia was observed when it was heated to 121℃ for 15 minutes to 150 minutes or 130℃,140℃,150℃,160℃,170℃ for 15 minutes When the temperature on 121℃ within 150 minutes or the temperature under 150℃ for 15 minutes When the temperature on 121℃ within 150 minutes or the temperature under 150r for 15 minutes,the color and gross、the dissolve property and the N CWS content were not significantly change compared with those of Bao Bi Jia before heat,the rates of suppressing the Mouse S180 growth of them were greater than 50% These results suggested that Bao Bi Jia resisted 121℃ for 150 minutes or 150℃ for 15 minutes。 KEY WORDS:Bao Bi Jia;Thermostability;Activity;Physicochemical propertiesn order to supply the referential data for clinical treatment of vessel deformity. Methods The mechanism and condition of thrombus formation by copper needle were studied in vivo and in vitro using electrophysics, atom absorption spectrophtometry, histological, and histochemical methods. Results Great deal of copper ion was dissociated, and agglutination of red blood cells(RBC) in blood could be observed in vitro after the current applied by copper needles. Formation of stable thrombus was related to voltage and time of application of electric current. Conclusion Dissociation of copper ion and agglutination of RBC are the basic principle of electrothrombosis with copper needle. A 4V direct current and 17.5 minutes are the safe and effective conditions for thrombus formation in the blood vessels.

关 键 词：胞必佳 热稳定性 活性 理化性质 抗癌药 

分 类 号：R979.1[医药卫生—药品]