牛膝多糖对兔膝骨关节炎血液流变学的影响  

Effect of Achyranthes Bidentata Polysaccharides on Hemorrheology of Rabbit's Knee Osteoarthritis

作　　者：邹来勇[1] 方芳 涂国卿[1] 汤群珍[1] 曹耀兴[1] 朱玉辉[1] 谢英[1] 

机构地区：[1]江西中医药高等专科学校,江西抚州344000 [2]抚州市妇幼保健医院,江西抚州344000

出　　处：《河南中医》2013年第12期2083-2085,共3页Henan Traditional Chinese Medicine

基　　金：江西省卫生厅中医药科研基金课题(编号:2012A048)

摘　　要：目的:观察牛膝多糖对兔膝骨关节炎血液流变学的影响。方法:选取6个月龄新西兰大白兔48只,采用改良Hulth模型造模,随机分为对照组和治疗组各24只。治疗组采用牛膝多糖的提取药物灌胃,对照组采用生理盐水灌胃。观察两组全血黏度、血浆黏度、凝血时间、血浆凝血酶原时间、血沉、红细胞电脉率及血浆纤维蛋白原含量的变化情况。结果:全血黏度、血浆黏度、血沉、纤维蛋白原、血细胞比容均有所下降,凝血酶原时间延长,红细胞电泳率加快。治疗组治疗后显著低于治疗前(P<0.05或P<0.01),对照组治疗前后比较无显著性差异(P>0.05);治疗前两组比较无显著性差异(P>0.05),治疗后治疗组显著低于对照组(P<0.05或P<0.01)。结论:牛膝多糖能改善全血黏滞度,改善血液循环,促进膝骨关节炎的修复。Abstract：Objective： To observe the effect of Achyranthes bidentata polysacchm＇ides on hemorrbeologgy of rabbit＇s knee osteoar- thrifts. Methods： With the modified Huhh model, 48 6-month-old New Zealand white rabbits were. randomly divided into control group and treatment group, with 24 rats in each group. Treatment group were treated with Achyranthes bidentata polysaccharide orally, the control group with normal saline. The whole blood viscosity, plasma viscosity, blood coagulation time, prothrombin time, erythrocyte sedimentation rate, electric pulse rate of red blood cells and the conlent change of plasma fibrinogen of two grot, ps were observed after the treatmenl. Results： The whole blood viscosity, plasma viscosity, erythrocyte sedimentation rate, fihrinogen and hematocrit decreased, the prothrombin time prolonged and the red cell electrnphoresis rale increased. In treatment group, after the treatment they were significantly lower than those before treatment （ P 〈 0.05 or P 〈 0.01 ） ; in the control group, no significant difference was found before and after the treatment （ P 〉 0.05 ） ; before the trealmenl, two groups showed no signifi- cant difference （ P 〉0.05）, after the treatment, the treatment group was significantly lower than that of the control group （ P 〈 0.05 or P〈 0.01 ）. Conclusion： Achyranthes bidentata polysaccharides can improve the whole blood viscosity, improve blood circulation, and promote the repair of knee osteoarthritis.

关 键 词：牛膝多糖 膝骨关节炎 血液流变学 大白兔 

分 类 号：R684.3[医药卫生—骨科学]