EQ-5D和SF-6D对中国稳定性心绞痛患者应用的效度和灵敏度评价  

Validity and Sensitivity of the SF-6D and EQ-5D in Chinese Patients with Stable Angina Pectoris

作　　者：韩月蓉[1] 吴晶[1] 丛洪良[2] 周津[2] 徐程[3] 

机构地区：[1]天津大学药物科学与技术学院300072 [2]天津胸科医院心内科 [3]西南财经大学公共管理学院

出　　处：《中国卫生统计》2013年第6期829-832,共4页Chinese Journal of Health Statistics

摘　　要：目的评价两个基于偏好的量表(EQ-5D、SF-6D)对中国稳定性心绞痛患者应用的效度和灵敏度。方法通过评价两个量表与西雅图心绞痛量表的相关性来考评其聚合效度,通过评价量表能否区分不同情况患者来考评其区别效度,通过计算相对效度以及操作者可接受曲线下面积,来考评量表对临床相关差异的灵敏度。结果 EQ-5D、SF-6D两个量表与西雅图心绞痛量表三个维度有较好的相关性(0.365≤r≤0.553,P<0.001),对于不同疾病状况的患者有较好的区别力(P<0.05),SF-6D灵敏度优于EQ-5D。结论从效度和灵敏度角度,EQ-5D和SF-6D量表适用于稳定性心绞痛患者的临床研究,但量表的选择需要依据具体的研究目的。Objective To validate the psychometric properties of two generic preference-based instruments（EQ-5D ,SF-6D） in Chinese patients with stable angina pectoris（SAP）. Methods Convergent validi- ty was accessed by examining their association with Seattle Angina Ques- tionnaire（SAQ）. ＂Known-group＂ method was used to examine their dis- criminative validity based on its ability to discriminate patients with differ- ent health status. Responsiveness was tested using relative efficiency （RE） and receiver operating characteristic（ ROC ） curves. Results Convergent validity was demonstrated by the moderate to strong correlation coefficients （0. 365 ≤ r≤0. 553, P 〈 0. 001 ）. Both measures were discriminated be- tween patients with different frequencies of the angina（ P 〈 0. 001 ）. RE and the areas under ROC showed that SF-6D was more efficient than EQ-5D. Conclusion This study provides evidence that EQ-5D and SF-6D are valid and sensitive preference-based HRQoL instruments in Chinese SAP patients.

关 键 词：稳定性心绞痛 EQ-5D SF-6D 效度 灵敏度 

分 类 号：R541.4[医药卫生—心血管疾病]