农村单采浆献血者HCV感染后的现状及其血清病毒载量与临床转归的相关性  

Current status of the apheresis plasma donors infected with hepatitis C virus after blood transfusion in Hebei rural areas and interrelation between their serum HCV RNA quantities and their clinical outcome

作　　者：陈红梅[1] 徐小元[2] 

机构地区：[1]西藏大学医学院传染病教研室,西藏拉萨850000 [2]北京大学第一医院感染疾病科

出　　处：《中国输血杂志》2013年第11期1087-1089,共3页Chinese Journal of Blood Transfusion

摘　　要：目的了解上世纪70～90年代我国农村单采浆献血者感染输血后丙型肝炎病毒后的现状及其HCV感染与疾病转归的相关性。方法调查河北省某地农村229名单采浆献血者HCV感染后的现状，包括血清ALT、病毒学标志检测，其中HCVitNA的测定采用荧光定量PCR方法，抗-HCV检测采用ELISA法，血清ALT检测采用赖氏法。结果229名农村单采浆献血者感染输血后HCV的慢性化率为57．64％；ALT异常率HCVRNA阳性组为46．97（62／132）、阴性组4．129（4／57）（P〈0．01）；ALT异常率抗．HCV阴性组、抗-HCV低滴度组对比数据及高滴度组分别为0、33．80％及42．84％（P〈0．01）。结论迄今为止我国农村单采浆献血者感染HCV的表现仍为慢性、隐匿性，肝酶学检查指标大多轻度到中度异常，随着HCVRNA载量增加抗-HCV阳性检出率和ALT的异常率增高，因此三者联合检测在正确诊断和预测他们的肝脏损伤及早期疗效观察中具有重要的意义。Objective To investigate tile current status of the apheresis plasma donors infected with hepatitis C virus af- ter blood transfusion in rarul heber areas during 1970 - 1990＇s , and to study the inten＇elation between their serum HCV RNA quantities and their clinical outcome. Methods The blood samples of 229 plasma donors, who were infected with hepatitis C virus after blood transfusion in Hebei rural areas were investigated,including the serum liver enzymes, virological markers, the detection of HCV RNA via fluorescence quantitative PCR methods, and anti-HCV detection via ELISA method. Results The ra.te of chronicity of these donors infected with HCV was 57.64%. ALT levels in the HCV RNA-positive group and negative groups were 46.97% and 4. 129%, respectively（ P 〈 0. 01 ）. ALT in the anti-HCV negative group, anti-HCV with low - ti- ter group and anti-HCV with high - titer group was 0, 33.80% and 42.84%, respectively. Conclusion So far, the a- pheresis plasma donors with HCV infection in Chinese rural areas still have chronic and latent clinical manifestations, and the test results of liver enzymes were mostly mild to moderate abnownal. With the increases of HCV RNA quantities,the positive detection rate of anti-HCV- and abnormal rate of ALT also increase. Therefore,three combined testing have great significance in the correct diagnosis, liver injury prediction and thte early observation of curative effect.

关 键 词：丙型肝炎病毒 献血者 单采血浆 HCV RNA 中国农村 

分 类 号：R446.6[医药卫生—诊断学] Q522.4[医药卫生—临床医学]