糖络宁对糖尿病大鼠坐骨神经能量代谢和神经传导速度的影响  

Effect of Tang Luo Ning on sciatic nerve energy metabolism and nerve conduction velocity in diabetic rat

作　　者：朱智耀[1] 高彦彬[1] 邹大威[1] 李步满[2] 彭继升[3] 周晖[4] 付修文[1] 王金羊[1] 张娜[1] 赵轩[1] 周盛楠[1] 李娇阳[1] 

机构地区：[1]首都医科大学中医药学院,北京100069 [2]北京大学首钢医院,北京100144 [3]北京中医药大学第三附属医院,北京100029 [4]北京中医药大学东方医院,北京100078

出　　处：《中国中医基础医学杂志》2013年第12期1410-1412,共3页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家自然科学基金资助项目(30873253)

摘　　要：目的:观察糖络宁(TLN)对糖尿病大鼠坐骨神经能量代谢和神经传导速度(NCV)的影响。方法:链脲佐菌素注射建立糖尿病大鼠模型并随机分为模型组和TLN组,另设正常对照组。TLN干预8周,检测坐骨神经MNCV和ATP、Pcr、Cr含量。结果:模型组与正常对照组比较,MNCV显著减慢,Pcr含量以及Pcr:Cr明显减低(P<0.05)。TLN组与模型组比较,MNCV和Pcr含量以及Pcr:Cr显著升高(P<0.05)。结论:TLN能够改善坐骨神经能量代谢,加快NCV,从而发挥其神经保护作用。Objective ：To study the effects of Tang luo ning（TLN） on energy metabolism and nerve conduction velocity of sciatic nerve in diabetic rats. Method ：Model of diabetic rats was induced by injection of streptozotocin. The diabetic rats were randomly divided into the model group and TLN group, and normal control group was also set up. After intervention with TLN for 8 weeks, We detected the MNCV and the content of ATP,Pcr,Cr in sciatic nerve. Results：Compared with the normal control group,the MNCV and the content of Pcr and ratio of Pcr： Cr decreased obviously in model group （P 〈 0.05 ）. Compared with the model group,the MNCV and the content of Pcr and ratio of Pcr：Cr increased significantly in TLN group （P 〈 0.05）. Conclusion： TLN can improve the energy metabolism and NCV to perform the neuro-protective effect.

关 键 词：糖络宁 糖尿病 大鼠 坐骨神经 能量代谢 神经传导速度 

分 类 号：R285.5[医药卫生—中药学]