白藜芦醇代谢模式的研究进展  

A Review of the Metabolic Pattern of Trans-Resveratrol

作　　者：杨阳[1] 李传刚[2] 舒晓宏[1] 

机构地区：[1]大连医科大学药学院,辽宁大连116044 [2]大连医科大学第二临床学院,辽宁大连116023

出　　处：《中国药学杂志》2013年第24期2081-2083,共3页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金资助项目(81072063;30971038);辽宁省高等学校杰出青年成长计划资助项目(LJQ2012078)

摘　　要：目的分析白藜芦醇的药物代谢模式的研究现状,探讨与生物活性相关的代谢方式。方法以国内外文献资料为基础,分别以体外培养的细胞体系、离体模型及动物、人在体模型为研究对象,对白藜芦醇的代谢形式进行分析。结果与结论现有文献研究表明,白藜芦醇的代谢模式主要以Ⅱ相反应为主,在细胞体系中以硫酸酯化为主,而在啮齿类动物和人体内则以硫酸酯化和葡萄糖醛酸苷化形式出现。白藜芦醇极低生物利用度与其广泛生物活性还有待于进一步探讨。OBJECTIVE To review the metabolic pattern of resveratrol, and reveal the bioaetive form to improve the consequent bioavailability of resveratrol. METHODS According to the domestic and foreign literatures, the numerous data including in vitro, and in vivo models were considered to analyze and summarize the metabolic spectrum of resveratrol. RESULTS AND CONCLUSION The presented results showed that phase II reactions were the major in the drug metabolic of resveratrol, and sulfation predominated in the human cell lines, but biological impacts of resveratrol and its metabolites as well as the synergistic effects should be focused on in the future to increase the bioavailability of resveratol.

关 键 词：白藜芦醇 药物代谢 生物活性 

分 类 号：R284[医药卫生—中药学]