氢气气泡模板电化学诱导沉积纳-微米二级结构钙磷盐生物材料的研究  

Study on Hydrogen Bubble Template Fabrication of Porous Biomaterials Coatings by Electrochemically Induced Deposition

作　　者：王卉[1,2] 林昌健[2] 胡仁[2] 张克勤[1] 段红平 董镶 

机构地区：[1]苏州大学现代丝绸国家工程实验室,纺织与服装工程学院,江苏苏州215123 [2]厦门大学固体表面物理化学国家重点实验室,化学化工学院化学系,福建厦门361005 [3]北京医用内植物工程技术研究中心,北京100082

出　　处：《电化学》2013年第6期501-506,共6页Journal of Electrochemistry

基　　金：国家科技支撑计划(No.2012BAI07B09);国家自然科学基金项目(No.51203108);江苏省自然科学基金项目(No.BK2011355);江苏省高校自然科学研究项目(No.11KJB430011)资助

摘　　要：生物材料的多孔结构对于植入后细胞的响应及其与机体组织的有效整合有着决定性的影响.采用电化学沉积方法在钛基表面成功制备多孔钙磷盐及钙磷盐/蛋白质复合膜层.本文选择合适的电解液浓度、温度、电流密度、时间和蛋白质添加剂等,可有效地控制钙磷盐晶体的形状、尺寸和柔韧性,并初步探讨了氢气气泡模板的作用机制.研究结果表明,动态氢气气泡是一种有效的模板,可控制钙磷盐晶体的生长速度,成功构筑纳-微米二级结构钙磷盐生物材料.So far, the pore architecture in biomaterials plays a critical role on the cell response and integration between the biomaterials and implanted environment. In this study, porous calcium phosphate（CaP） coatings and CaP/protein composite coatings have been successfully constructed on titanium substrate by using an electrochemically induced deposition technique. The shape, size and pliability of CaP crystals are controlled by electrolyte concentration, temperature, current density, time and protein additive in preparing process. In addition, the formation mechanism of the porous structure is discussed based on the ＂hydrogen bubble template＂ model. It demonstrates that the growth velocity of CaP crystals should match well with the forming-disappearing velocity of hydrogen bubble, and the pliability of the CaP crystals should fit with soft bubble. As a result, dynamic hydrogen bubble can act as an effective template to construct the nano-micro porous structured biomaterials coatings by controlling the growth velocity of CaP crystals.

关 键 词：多孔结构 钛 电化学诱导沉积 气泡模板 生物材料 

分 类 号：O646[理学—物理化学]