氯乙烯接触工人氧化损伤指标的变化  

Variation in Oxidative Injury Markers in Vinyl Chloride Monomer Exposed Workers

作　　者：冀芳[1,2] 张建[3] 王琪[1] 郑颖佳[1] 柴尚建[4] 李俊[4] 夏昭林[1] 

机构地区：[1]复旦大学公共卫生学院劳动卫生教研室,公共卫生安全教育部重点实验室,上海200032 [2]新疆维吾尔自治区安全科学技术研究院,新疆830002 [3]新疆维吾尔自治区疾病预防控制中心,新疆830002 [4]上海氯碱化工股份有限公司,上海200241

出　　处：《环境与职业医学》2013年第12期903-907,共5页Journal of Environmental and Occupational Medicine

基　　金：国家自然科学基金(编号:30070650);上海市公共卫生体系建设三年计划(编号:08GWD12);上海市劳动卫生学公共卫生重点学科建设计划(编号:08GWZX0402)

摘　　要：[目的]探讨氯乙烯(VCM)接触工人体内氧化损伤指标的变化,筛选可能的氯乙烯接触效应生物标志物。[方法]以359名氯乙烯接触工人为接触组,158名不接触氯乙烯的工人为对照组,测定血清中超氧化物歧化酶(SOD)、丙二醛(MDA)以及谷胱甘肽硫转移酶(GST)的含量。[结果]多元线性回归分析结果显示,各VCM累积接触剂量组与对照组相比,SOD活性降低(P<0.001)而MDA活性增高(P<0.001)。低剂量组和高剂量组与对照组相比,GST水平增高(P<0.05)。趋势卡方检验结果显示,VCM累积接触剂量与SOD和GST活性间存在明显的剂量-反应关系。[结论]在目前的VCM接触浓度下,VCM可造成氧化损伤指标的改变。认为MDA、SOD、GST可作为VCM暴露评价的效应生物标志物。[ Objective ] To screen potential effect biomarkers for vinyl chloride monomer （VCM） exposure by understanding oxidative injury induced by VCM. [ Methods ] A group of 359 workers occupationally exposed to VCM were selected as the exposed group, and 158 workers without VCM exposure were selected as the control group. Activities of serum superoxide dismutase （SOD）, malondialdehyde （MDA）, glutathione S-transferase （GST） were determined. [ Results ] The results of multiple linear regression showed that the serum SOD activity of the VCM-exposed groups （three dose levels） decreased significantly compared with the control group （P 〈 0.001）, and the activity of MDA increased （P 〈 0.001）. The GST activities in the low and high exposure groups were significantly higher than that of the control group （P 〈 0.05）. The results of Chi-square test showed a dose-response relationship between the serum levels of SOD/GST and the cumulative exposure dose of VCM. [ Conclusion ] The oxidative hazard of VCM exposure is obviouse under the current VCM exposure level. The activities of serum SOD, MDA, and GST could be used as effect biomarkers for VCM exposure assessment.

关 键 词：氯乙烯 超氧化物歧化酶 丙二醛 谷胱甘肽硫转移酶 生物标志物 

分 类 号：R135[医药卫生—劳动卫生]