球形细胞和椭球形红细胞在极低频电磁场中的微剂量计算  

Microdosimetric calculation of spherical cells and ellipsoidal red blood cells in an extremely low frequency electromagnetic field

作　　者：鲁维[1] 王宏[2] 周红梅[1] 苏镇涛[1] 宁静[1] 王长振[1] 纪云龙[1] 曲德成[1] 张晓敏[1] 潘洁[1] 吴可[1] 谢向东[1] 杨国山[1] 

机构地区：[1]军事医学科学院放射与辐射医学研究所,北京100850 [2]中国医学科学院北京协和医学院生物医学工程研究所,天津300192

出　　处：《军事医学》2013年第11期814-817,826,共5页Military Medical Sciences

基　　金：国家自然科学基金资助项目(61101032);国家973计划资助项目(2011CB503701)

摘　　要：目的计算极低频电磁场中球形细胞和椭球形红细胞(RBC)的电场强度和跨膜电压,为极低频电磁场与生物体相互作用靶点和机制的探寻提供参考依据。方法针对球形细胞模型和椭球形RBC模型,利用有限元法进行数值计算。结果两种细胞模型细胞膜电场强度最大值均明显高于外加电场强度,且细胞膜电场强度和跨膜电压随电场方向成周期性变化。结论较之细胞电磁参数,细胞形状及外电场方向对细胞膜电场强度和跨膜电压的影响并不大,细胞膜电场强度和跨膜电压的分布与外加电场方向有关。Objective To calculate the electric field intensity and transmembrane voltage of spherical cells and ellipsoi -dal red blood cells （ RBC） in an extremely low frequency electromagnetic field .Through this calculation , we can provide reference to the search for interaction targets and mechanics between the extremely low frequency electromagnetic field and organisms.Methods The Finite Element Method was used in the numerical computation for the spherical cell model and the ellipsoidal RBC model .Results The electric field intensity of the two types of cells on the cellular membrane was both significantly higher than the applied electric field strength , and the values of the induced field strength and transmembrane voltage varied with the direction of the electric field periodically .Conclusion The cell shape and direction of the applied electric field are not the main determinants of the cellular membrane electric field intensity and the transmembrane voltage compared with electromagnetic parameters .The distribution of the electric field intensity and transmembrane voltage are re-lated to the direction of the applied electric field.

关 键 词：电磁场 单细胞 电场强度 跨膜电压 极低频 

分 类 号：Q27[生物学—细胞生物学]