吸烟对终末期肾病患者全段甲状旁腺激素与左心室重塑的影响  

The effects of smoking on intact parathyroid hormone and left ventricular remodeling in the end stage renal disease patients

作　　者：郭洋洋[1] 张陆齐 

机构地区：[1]河北省廊坊市第四人民医院内二科,河北廊坊065700

出　　处：《中国处方药》2013年第6期27-30,共4页Journal of China Prescription Drug

摘　　要：目的研究并分析吸烟对终末期肾病患者全段甲状旁腺激素(iPTH)水平的影响以及与左心室重塑的关系。方法根据吸烟情况将139例慢性肾小球肾炎终末期肾病非透析患者分组,测定各组的iPTH及其他临床化验指标,并计算各组左心室质量指数(LVMI)。分析吸烟对iPTH的影响以及与LVMI的相关性。结果吸烟组iPTH高于不吸烟组,重度吸烟组iPTH高于轻度吸烟组,吸烟与iPTH独立正相关,且iPTH随着吸烟量增加而升高,呈剂量依赖关系;有左心室肥厚组iPTH高于无左心室肥厚组,iPTH与LVMI独立正相关。结论血iPTH指标的提升是终末期肾病吸烟患者高发左心室肥厚症状的关键因素,值得临床重视。Objective To study and analyse the effects of smoking on intact parathyroid hormone and the relationship between smoking and leti ventricular remodeling in the end stage renal disease patients. Methods 139 end-stage renal disease of chronic glomemlonephritis non-dialysis patients were divided into groups according to the situation of Smoking. To detecte the patients＇ s iPTH and other clinical laboratory indicators in each group, and calculate left ventricular mass index （LVMI）. Then analyzed the correlation between smoking and the parathyroid hormone and LVMI. Results iPTH in the smoking group was higher than that in the no smoking group, and iPTH m the heavy smoking group was higher than that in the light smoking group either. Smoking was positively independent correlated with iPTH which increased with increasing amount of smoking, iPTH in the group that patients with left： ventricular hypertrophy was higher than that without left ventricular hypertrophy, and iPTH had a positive correlation with left ventricular hypertrophy, Conclusion The increasing of Blood iPTH index is the key factor much contributing to left ventricular hypertrophy for end-stage renal disease patients who were smoking, which is worth to be concerned.

关 键 词：吸烟 血全段甲状旁腺激素 左心室肥厚 终末期肾病 

分 类 号：R692.5[医药卫生—泌尿科学]