多维谱效关系在中药研究中的进展  

Advances of multi-dimensional spectrum-effect relationship for the research on traditional Chinese medicine

作　　者：孙莉琼[1] 戚进[1] 余伯阳[1] 

机构地区：[1]中国药科大学中药复方研究室,南京210009

出　　处：《中国药科大学学报》2013年第6期487-493,共7页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.81274004;No.30973965);"十一五"国家科技支撑计划资助项目(No.2008BAI151B03);江苏省高等学校优秀科技创新团队~~

摘　　要：中药的质量直接关系到其临床疗效和安全性。近年来,国内外学者开展了大量的中药谱效关系的研究工作,试图将中药指纹图谱中表征的化学成分与药效活性相结合,从而建立与中药产品疗效相关且反映其内在品质的质量标准。然而,中药成分复杂,对疾病的治疗往往是多种成分通过多靶点和多环节发挥整体作用。鉴于此,本文结合作者课题组的前期研究工作,提出中药多维谱效关系这一概念,并选择与疗效密切相关的多种药效指标探讨谱效关系,为进一步完善中药质量评价体系提供新的研究思路和方法。The therapeutic effect and safety of traditional Chinese medicine （TCM） are known to directly depend on its quality. In the past decade, a lot of researchers have undertaken many researches on spectrum-effect rela- tionship of TCM in an attempt to associate the chemical composition in fingerprint chromatograms with its pharma- codynamic activity, and to establish scientific quality standards which accord with the efficacy of Chinese medici- nal products and reflect their intrinsic quality. In this paper, due to the complexity and pharmacological diversity of the constituents of TCM, a concept of the ＂multi-dimensional spectrum-effect relationship＂ was proposed, and a variety of pharmacodynamic activities referring to the clinical effects were selected to explore this new model based on the author＇s own research experiences. It could provide some reference for further improvment of the quality evaluation system of TCM.

关 键 词：谱效关系 多维 质量评价 在线活性检测 中药 

分 类 号：R284.1[医药卫生—中药学]