肿瘤靶向药物输送载体研究的分析和展望  

Perspectives on targeted nano-drug carriers for tumor treatment

作　　者：徐宇虹[1] 曹婧[1] 

机构地区：[1]上海交通大学药学院,上海200240

出　　处：《中国药科大学学报》2013年第6期494-503,共10页Journal of China Pharmaceutical University

摘　　要：随着纳米技术的发展,靶向肿瘤的纳米载体成为研究的热点。纳米载体可以通过靶向作用更有效地输送抗肿瘤药物和影像材料用于肿瘤的治疗和诊断。本文对靶向肿瘤的纳米药物载体研究的近况以及发展趋势进行分析和展望,希望从靶向载体制剂设计和开发的角度出发,探讨靶点选择、靶向机制以及载体结构和质量控制方面的关键技术问题,期望对相关研究人员有所启发。Recent advances in nanotechnology raises exciting opportunities for generating new cancer therapies that might allow more efficient targeted delivery of antieancer agents to kill tumors and imaging agents for diagno- sis of various cancers. In this article, some new perspectives were provided on the development of targeted nano- drug carriers for cancer treatment. The focus was not to review research articles published on the subject, but to discuss issues we considered critical concerning target selection, targeting mechanism, and carrier structure de- sign. We hope such discussions would encourage more detailed and careful studies to support product develop- ment of targeted drug carriers for cancer treatment.

关 键 词：肿瘤靶向 纳米药物载体 靶点选择 靶向机制 

分 类 号：R944[医药卫生—药剂学]