丹红化瘀口服液联合胰岛素对早期糖尿病肾病的防治作用(英文)  

Effect of Danhong Huayu Koufuye combined with insulin on prevention and progression of early diabetic nephropathy in rats

作　　者：钟春梅[1] 马燕[1] 王延东[2] 杨威 韩重 孙晶晶[4] 林宝琴[1] 

机构地区：[1]广州中医药大学中药学院,广州510006 [2]中山大学中山眼科中心,广州510060 [3]广州医药研究总院有限公司,广州510260 [4]美国太平洋大学药剂学与健康学院,斯托克顿市95211

出　　处：《中国药科大学学报》2013年第6期568-572,共5页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.81303282);广州市珠江科技新星专项资助项目(No.2013J2200034);广州中医药大学青年英才培养资助项目

摘　　要：丹红化瘀口服液是传统中药复方,具活血化瘀、行气通络的功效。观察丹红化瘀口服液、胰岛素及两者联合用药对糖尿病肾病大鼠的治疗效果。采用链脲佐菌素(STZ)诱导糖尿病肾病大鼠模型,STZ注射后1周后将造模成功的大鼠随机分为4组:糖尿病模型组、胰岛素组、丹红化瘀口服液组,丹红化瘀口服液联合胰岛素组,另设一正常组,每天给药1次,连续15周。丹红化瘀口服液联合胰岛素用药比两者单独用药能更显著降低空腹血糖、24 h饮水量、摄食量和尿量,降低血清尿素与尿素/肌酐比,改善肾脏肥大和肾组织病理损伤,同时提高血清Na+与Cl-水平。结果提示:丹红化瘀口服液可辅助胰岛素治疗糖尿病肾病。Danhong Huayu Koufuye （DHK）, a traditional Chinese prescription, has activities of promoting blood circulation to remove blood stasis and promoting qi circulation to remove meridian obstruction. The aim of the study was to investigate effects of DHK, insulin and their combination on diabetic nephropathy （DN） in streptozo- tocin （STZ, 50 mg/kg, ip）-induced diabetic Sprague-Dawley rats. Rats were divided into five groups： normal control, model control, insulin, DHK, and DHK plus insulin. The animals were treated once daily for 15 weeks starting one week after STZ injection. The combination of DHK with insulin resulted in more significant effects than insulin or DHK alone on decreasing fasting blood glucose, 24 h water intake, diet intake and urine volume, reducing serum urea level and urea-to-Cr ratio, promoting kidney hypertrophy and renal damage, and increasing serum Na ＋ and Cl- level as well. These results suggest that DHK may be a valuable adjuvant therapy for DN.

关 键 词：丹红化瘀口服液 糖尿病肾病 链脲佐菌素 糖尿病 胰岛素抵抗 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]