乏氧细胞线粒体与肿瘤辐射抗性  

Hypoxia Mitochondria and Tumor Radiation Resistance

作　　者：何阳[1,2,3,4] 周鑫[1,2,3] 张红[1,2,3] 

机构地区：[1]中国科学院近代物理研究所,甘肃兰州730000 [2]中国科学院重离子束辐射生物医学重点实验室,甘肃兰州730000 [3]甘肃省重离子束辐射医学应用基础重点实验室,甘肃兰州730000 [4]中国科学院大学,北京100049

出　　处：《原子核物理评论》2013年第4期488-493,共6页Nuclear Physics Review

基　　金：国家重点基础研究发展计划项目(973计划)(2010CB834202);国家自然科学基金资助项目(10835011;10675151);甘肃省重大科技专项项目(0702NKDA045;0806RJYA020);中国科学院西部之光人才培养计划项目(XB106012)~~

摘　　要：综述了乏氧环境对细胞整体和对线粒体的影响,正常细胞线粒体呼吸链在乏氧环境下的损伤及其与肿瘤的关系,并对肿瘤细胞适应乏氧环境的机制进行了阐述。总结了线粒体作为供能细胞器,对肿瘤细胞在乏氧条件下生长、侵袭和转移及获取能量过程中的作用,并介绍了中国科学科院近代物理研究所利用重离子辐照所做的相关研究成果,包括不同剂量重离子对线粒体DNA超螺旋构象及线粒体功能的影响,同一剂量不同时间重离子辐照后对线粒体DNA 4977大片段损伤累积的影响。The hypoxia environment on the cells and mitochondria, and the damage of normal cells mitochondrial respiratory chain in hypoxia and its relationship with tumors are reviewed. In addition, the tumor radiation resistance mechanism in hypoxia are summarized. It also expounds that mitochondria, as energy supply organelles for cells, are related to tumor ceils growth, invasion and metastasis in hypoxia environment, besides, it gives a brief introduction to the mitochondria study of the Institute of Modem Physics, Chinese Academy of Sciences with heavy ion irradiation, including effects of different dose of heavy ion on mitochondrial DNA superhelix conformation and function of mitochondria, and the influence on mitochondrial DNA 4 977 damage cumulation in different time after the same dose of heavy ion irradiation.

关 键 词：乏氧 线粒体 肿瘤 辐射抗性 

分 类 号：Q691[生物学—生物物理学]