糖化血红蛋白与冠状动脉病变特点相互关系的研究  

The relationship between HbA1c and characteristics of coronary artery lesions

作　　者：冯新星[1] 吴亚杰[2] 宋莹[2] 王东[2] 张茵[2] 陈伊[3] 王怡璐[4] 王继征[4] 巩秋红[1] 邹玉宝[2] 宋雷[2] 袁晋青[2] 孙凯[4] 陈燕燕[1] 

机构地区：[1]中国医学科学院,北京协和医学院,国家心血管病中心,阜外心血管病医院内分泌科 [2]中国医学科学院,北京协和医学院,国家心血管病中心,阜外心血管病医院心内科 [3]中国医学科学院,北京协和医学院,国家心血管病中心,阜外心血管病医院心外科恢复室 [4]中国医学科学院,北京协和医学院,国家心血管病中心,阜外心血管病医院心血管疾病国家重点实验室

出　　处：《中国分子心脏病学杂志》2013年第6期711-713,共3页Molecular Cardiology of China

基　　金：973计划项目(2010CB732601);院所青年基金支持项目(2013-F10)

摘　　要：目的探讨糖化血红蛋白与冠状动脉病变特点的相互关系。方法入选在我院住院的患者1375例,检测糖化血红蛋白,并行冠脉造影术,以Gensini评分评价患者冠状动脉狭窄程度,冠脉病变特点以冠脉病变支数及冠脉狭窄程度来表示。结果糖化血红蛋白与冠脉病变支数显著相关。糖化血红蛋白与Gensini积分呈正相关。在校正了年龄、性别、体重指数、吸烟、饮酒、收缩压、舒张压、肌酐、尿酸、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三脂、空腹血糖、高敏C反应蛋白等危险因素后,糖化血红蛋白与Gensin积分的相关性仍存在。结论糖化血红蛋白升高与冠脉狭窄程度加重相关,同时与累及的冠脉支数增加相关。Objective This study is to investigate the relationship between HbAlc and the characteristics of coronary artery lesions. Methods A total of 1375 patients who were suspected coronary artery disease were enrolled. All these patients underwent coronary artery angiography. HbA 1 c also was inspected. The characteristics of coronary artery lesions were assessed by severity of coronary artery stenosis and the number of coronary vessels with stenosis. Results HbA 1 c significantly correlates with the number of coronary vessels with stenosis. There is a positive correlation between HbAlc and the Gensini score. After adjustment for age, sex, BMI, smoking, drinking, SBP, DBP ,Cr ,UA, CHOL, TG, LDL-C, HDL-C, FBG and HsCRP, HbAlc still correlates with gesini score. Conclusion The increasing of HbAlc correlates with severity of the coronary artery stenosis and the number of coronary vessels with stenosis.

关 键 词：糖化血红蛋白 冠状动脉 病变特点 相互关系 

分 类 号：R446.1[医药卫生—诊断学] R543.3[医药卫生—临床医学]