磷酸肌酸钠对阿霉素所致心肌病理改变和超微结构的影响  

The effects of sodium phosphocreatine on Myocardial Pathological and ultrastructure Changes Caused By adriamycin

作　　者：邱祥春[1] 孙桂丽[1] 张雪彬[2] 侯斯琴高娃[1] 赵明[1] 

机构地区：[1]内蒙古民族大学附属医院,通辽市028000 [2]通辽市医院肿瘤科,通辽市028000

出　　处：《中国分子心脏病学杂志》2013年第6期759-761,共3页Molecular Cardiology of China

摘　　要：目的磷酸肌酸钠对阿霉素所致心肌病理改变和超微结构的影响。方法 60只雄性Balb/c小鼠分为磷酸肌酸钠干预组,阿霉素组和正常对照组,观察小鼠的一般情况,于14d观察心肌病理及超微结构改变,计算心肌病理组织学积分。结果阿霉素组心肌超微结构改变重于磷酸肌酸钠干预组,磷酸肌酸钠干预组与模型组比较病理积分下降明显,差异有统计学意义(P<0.01)。结论磷酸肌酸钠能有效地维护其心肌纤维及膜系统的稳定性,对阿霉素所致的心肌损伤具有保护作用。Objective To study the effects of sodium phosphocreatine on Myocardial Pathological and ultrastructure Changes Caused By adriamycin Methods sixty male Balb/c randomly divided into control group,adriamycin group,sodium phosphocreatine treatment group.On the 14th day, the myocardial ultrastructure and pathologic al changes were observed to calculate myocardial histologic points. Results The myocardial ultrastructures changes of the adriamycin group were more severe than that of the treatment group, the pathological integral of the treatment group decreased significantly, the difference was statistically significant （P 〈0.01）. Conclusion The above results suggested that sodium phosphocreatine effectively maintain the myocardial fibers and membrane system stability and protects mice from adriamycin-induced cardiotoxicity.

关 键 词：磷酸肌酸钠 阿霉素 超微结构 

分 类 号：R965[医药卫生—药理学]