平胃散中麸炒苍术用生苍术替代前后药效学比较研究  

Comparative Study on Pharmacodynamics of Rhizoma Atractylodis and Processed Rhizoma Atractylodis in “Pingwei Powder”

作　　者：徐敬儒[1] 刘玉强[1] 才谦[1] 王丹凤[1] 白忠旭[1] 

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600

出　　处：《上海中医药大学学报》2013年第6期78-81,共4页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：国家中医药管理局中医药行业科研专项项目(20110700712);国家自然科学基金资助项目(81202919)

摘　　要：目的:探讨平胃散中君药麸炒苍术用生苍术替代前后健脾作用的差异。方法:70只SD大鼠随机分为空白对照组、模型组、阳性药组及高、低剂量生苍术入药平胃散组和高、低剂量麸炒苍术入药平胃散组。除对照组外,大鼠均用大黄浓煎剂灌胃造模;各用药组再经上述药液干预治疗。检测各组大鼠血清中血管活性肠肽(VIP)、一氧化氮(NO)、胃泌素(GAS)、淀粉酶(AMS)、D-木糖分泌的影响。结果:造模后,对照组与模型组比较,体质量、进食量及各项血清指标差异均有统计学意义(P<0.05);各治疗组与模型组比较,体质量、进食量及各项血清指标差异均有统计学意义(P<0.05);麸炒苍术入药平胃散组与相同剂量生苍术入药平胃散组血清GAS差异均有统计学意义(P<0.05),麸炒高组与生高组血清NO、D-木糖差异亦有统计学意义(P<0.05)。结论:平胃散通过调节血清NO、GAS、D-木糖等起到治疗湿困脾胃证的作用,且麸炒苍术入药的平胃散之药效明显优于生苍术入药者,证明平胃散中选用麸炒苍术入药的合理性和科学性。Objective ： To discuss the different strengthening spleen effects of Rhizoma Atractylodis and processed Rhizoma Atractylodis in ＂Pingwei Powder＂. n^aods： Seventy SD rats were randomly divided into blank control group, model group, positive medicine group, ＂Pingwei Powder＂ with raw Rhizoma Atractylodis groups （ high, low dose） and ＂Pingwei Powder＂ with processed Rhizoma Atractylodis groups （high, low dose）, Except for control group, the models were established by Radix et Rhizoma Rhei intragastfically; each group was treated with corresponding medicine. The contents of VIP, NO, GAS, AMS and D-xylose were detected. Results： After modeling, there were significant differences in weight, food-intake and serum indexes between control group and model group significantly （ P 〈 0.05 ） ; with significant difference between treatment group and model group （ P 〈 0.05 ） ; there was significant difference in GAS between raw Rhizoma Atractylodis group and processed Rhizoma Atractytodis group （ P 〈 0.05 ）, and there were significant differences in NO and D-xylose between high-dose raw Rhizoma Atractylodis group and high-dose processed Rhizoma Atractylodis group （ P 〈 0.05 ）. Conclusion ： ＂Pingwei Powder＂ can recover the spleen deficiency syndrome by regulating NO, GAS and D-xylose. ＂Pingwei Powder＂ with processed Rhizoma Atractylodis has better effect than that with raw Rhizoma Atractylodis. It is reasonable and scientific.

关 键 词：平胃散 苍术 药效学 炮制 大鼠 

分 类 号：R285.5[医药卫生—中药学]