磷酸钙作为佐剂应用在乙肝核酸疫苗中的可能性研究  

Study of the Possibility on Calcium Phosphate as Adjuvant for Hepatitis B Nucleic Acid Vaccine

作　　者：焦建明[1] 刘宇珠[2] 

机构地区：[1]大理医学院传染病学教研室,云南大理671000 [2]大理州卫生防疫站学校卫生科

出　　处：《大理医学院学报》2000年第4期5-7,共3页Journal of Dali Medical College

摘　　要：目的：研究使用磷酸钙作为乙肝 DNA疫苗的佐剂，诱导机体免疫反应的可能性。方法：磷酸钙与疫苗 DNA制备出磷酸钙-DNA共沉物，免疫小鼠，检测外周血抗体，观察免疫应答反应。结果：磷酸钙-DNA共沉物能激发机体免疫应答反应。结论：佐剂在核酸疫苗的应用值得进一步研究。∶ Objective∶ To study the possibility of calcium phoophate as an adjuvant for hepatitis B nucleic acid vaccine.Methods∶ The hepatitis B nucleic acid vaccine was combined with the calcium phosphate to produce coprecipitation and used this coprecipitation to immunize the mice.Then examined the anti-HBs to observe the immune response.Results∶ Calcium phosphate DNA coprecipitation can induce the immune response.Conclusion∶ Using adjuvant in nucleic acid vaccine deserves to be further studiesd

关 键 词：磷酸钙 佐剂 核酸疫苗 免疫应答 乙型肝炎疫苗 

分 类 号：R512.620.1[医药卫生—内科学]