Diffusion-weighted MRI在家兔电烧伤后应用初步研究  

Prelimiary study of Diffusion-weighted MRI after electrical burn in rabbits

作　　者：欧志强[1,2] 陈松[1,2] 梁佩虹 李振辉[1,2] 

机构地区：[1]暨南大学医学院第四附属医院 [2]广州市红十字会医院放射科,510220

出　　处：《中国医疗前沿》2013年第20期1-2,共2页China Healthcare Innovation

基　　金：广东省广州市医药卫生科技项目(编号:20112131220090)

摘　　要：目的观察兔后肢电烧伤后磁共振弥散加权成像(MR-DWI)表面扩散系数(ADC)的变化规律。方法 12只新西兰大白兔随机数字表法分为烧伤组及对照组,于电烧伤后24h、48h及72h行伤肢MRI扫描,DWI成像b值分别选取50s/mm2、100s/mm2、300s/mm2同时进行T2WI及T1WI扫描,组织病理学检查。结果各烧伤组ADC值低于对照组,在b=300mm2/s时,烧伤后48h病变组与对照组之间差异存在统计学意义(P<0.05)。结论采用b值弥散成像(DWI)能够监测肌肉烧伤后病理变化过程,ADC值可以作为检测烧伤程度的影像观察指标。Objective To observe apparent diffusion coefficient（ADC） changes after rabbits electric burn. Methods Twelve healthy New Zealand white rabbits were equally randomized into burn group and control groups（post-burn at 24, 48 and 72h respectively）. They were imaged with a 1.5T MRI protocol to obtain T2WI, T1WI and DWI with ADC maps using b values of 50, 100, 300s/mm2, and histological examinations were conducted on burn muscles. Result The ADC of burn groups was lower than the control group. ADC of 48 h group were significantly lower than that of control group（P 〈0.05） when b=300s/mm2. Conclusion DWI is sensitive to characterize the histopathologic changes with b values and ADC may be a useful parameter in assessing degree of burn.

关 键 词：弥散加权成像 电烧伤 兔 磁共振成像 

分 类 号：R445[医药卫生—影像医学与核医学] R647[医药卫生—诊断学]