中药灌肠联合柳氮磺胺吡啶治疗慢性溃疡性结肠炎随机平行对照研究  

Enema Combined Sulfasalazine Treatment of Chronic Ulcerative Colitis Randomized Controlled Study

作　　者：张晓殷 

机构地区：[1]中国航空工业集团公司洛阳电光研究所职工医院内科,河南洛阳471000

出　　处：《实用中医内科杂志》2013年第7期130-132,共3页Journal of Practical Traditional Chinese Internal Medicine

摘　　要：[目的]观察中药灌肠联合柳氮磺胺吡啶治疗慢性溃疡性结肠炎疗效。[方法]使用随机平行对照方法，将90例住院患者按随机数字表法分为两组。对照组45例柳氮磺胺吡啶，1．0g／次，3次／d，口服。治疗组45例中药灌肠，黄连5g，广木香、茯苓、地榆、白术、乌梅各15g，五倍子、甘草各10g，山药、五味子各20g，党参30g；2次／d，水煎200mL，早晚100mL插）入肛门6～10cm灌肠。西药治疗同对照组。连续治疗7d为1疗程。观测临床症状、不良反应。连续治疗4疗程，判定疗效。[结果]治疗组显效19例，有效23例，无效3例，总有效率93．33％。对照组显效13例，有效24例，无效8例，总有效率82．22％。治疗组疗效优于对照组（尸〈O．05）。[结论]中药灌肠联合柳氮磺胺吡啶在治疗慢性溃疡性结肠炎效果显著，值得推广。[ Objective ] To observe the effect enema combined sulfasalazine treatment of chronic ulcerative colitis . [ Methods ] Using randomized controlled method, 90 cases of hospitalized patients were randomly divided into two groups . Control group, 45 cases of sulfasalazine , 1.0g / time, 3 times / d, orally. Enema treatment group 45 cases , Huanglian 5g, Guangmuxiang, Fuling , Diyu , Baishu, Wumei each 15g, Wubeizi, Gancao each 10g, Shanyao, Wuweizi each 20g, Dangshen 30g; 2does/d, decoction 200mL, sooner or later 100mL inserted into the anus 6 - 10cm enema. Western medicine with the control group . 7d is a continuous course of treatment. Observation of clinical symptoms and adverse reactions. Four cycles of continuous treatment , to determine efficacy . [ Results ] treatment group, 19 cases were markedly effective in 23 cases, 3 cases, the total efficiency of 93.33% . Control group, 13 cases were markedly effective in 24 cases, 8 cases, the total efficiency of 82.22% . Treatment group than the control group （ P〈0.05 ） . [Conclusion ] enema combined sulfasalazine in the treatment of chronic ulcerative colitis, the effect is significant , worthy of promotion.

关 键 词：慢性溃疡性结肠炎 中药灌肠 柳氮磺胺吡啶 随机平行对照研究 

分 类 号：R256.34[医药卫生—中医内科学] R289.5[医药卫生—中医学]