左氧氟沙星和头孢呋辛治疗鼻窦炎的对比观察  

Comparison of the effectiveness of levofloxacin and cefuroxime for the treatment of sinusitis

作　　者：李学佩[1] 覃卓明[2] 郑溶华[1] 檀庆兰[1] 周玉英[1] 朱丽[1] 殷安凡 

机构地区：[1]北京大学第三医院耳鼻咽喉科,北京100083 [2]北京双鹤药业医学部

出　　处：《临床耳鼻咽喉科杂志》2000年第12期573-575,共3页Journal of Clinical Otorhinolaryngology

摘　　要：目的 :观察左氧氟沙星和头孢呋辛治疗鼻窦炎的临床疗效。方法 :随机选择急、慢性鼻窦炎患者 ,用左氧氟沙星和头孢呋辛两组进行 2周口服治疗 ,左氧氟沙星组 76例 ,头孢呋辛组 14例。治疗前后进行临床和实验室检查 ,2周后进行疗效和安全性评估。结果 :左氧氟沙星组有效率为 97.4% ,头孢呋辛组为 92 .8% ;细菌清除率两组分别为 91.6 %和 80 .0 %。两组均有较高安全性。结论 :左氧氟沙星是治疗急、慢性鼻窦炎的有效药物 ,治疗时应注意用药疗程。Objective:To observe the effectiveness of levofloxacin and cefuroxime for the treatment of sinusitis in adults.Method:Patients with acute or chronic sinusitis were randomly assigned to receive either levofloxacin (200 mg orally once daily,200/100 mg twice daily) or cefuroxime (250 mg orally twice daily) for 10 to 14 days. Pre or post treatment, the clinical and laboratory examination were done and in the end of treatment, the efficacy and safety were assessment.Result:The success rates after the end of treatment were 97.4 % for the 76 patients who received levofloxacin and 92.8 % for the 14 patients who received cefuroxime. The resolution rates of bacteria were 91.6 % and 80.0 %, respectively. The safety of these two groups were more high.Conclusion:Levofloxacin is effective for the treatment of sinusitis in adults and pay attention to the course of treatment for raising the efficacy of treatment.

关 键 词：鼻窦炎 左氧氟沙星 头孢呋辛 

分 类 号：R765.410.5[医药卫生—耳鼻咽喉科]