早发冠心病患者危险因素与冠状动脉病变的关系  

Association between Smoking and Coronary Artery Lesion in Patients with Premature Coronary Artery Disease

作　　者：鲁明[1] 高炎[1] 王宁夫[1] 许轶洲[1] 李虹[1] 徐鹏[1] 

机构地区：[1]浙江省杭州市第一人民医院心血管内科,310006

出　　处：《心电与循环》2013年第6期481-482,485,共3页Journal of Electrocardiology and Circulation

基　　金：杭州市科技局重点项目(2008033Q03)

摘　　要：目的探讨早发冠心病患者吸烟与冠状动脉病变的关系及其意义。方法选取经冠状动脉造影确诊的PCAD患者270例,其中男性158例、女性112例,采集患者吸烟史(吸烟年数、每日吸烟支数)、血脂水平(HDL-C、LDL-C、TG、TC),记录患者冠状动脉造影结果,同时进行相关性分析。结果吸烟指数与冠状动脉慢血流之间存在正相关(r=0.156,P<005);HDL-C与吸烟指数及Gensini积分均呈负相关(r=-0.136、-0.156,均P<0.01);吸烟指数与Gensini积分之间无线性相关关系(r=0.084,P>0.05)。结论早发冠心病患者吸烟与HDL-C水平下降和冠状动脉慢血流现象相关。Objective To assess association between smoking and coronary artery lesion in patients with premature coronary artery disease （CAD）. Methods 270 patients （158 male, age〈55y and 112 female, age〈65y）with premature CAD determined by coronary angiography were enrolled. Smoking amount, blood lipids and coronary artery angiograph- ic results were analyzed. Results There was a positive correlation between smoking index and coronary slow-flow phenomenon （r=0.156, P〈0.05）. HDL-C was negatively correlated with smoking index （r=-0.136） and Gensini score （r=-0.156）（all P〈0.05）. There was no correlation between smoking index and Gensini score （r=0.084, P 〉0.05）. Con- clusion Smoking is related to HDL-C decline and coronary slow flow phenomenon in patients with premature CAD.

关 键 词：早发冠心病 危险因素 吸烟 

分 类 号：R541.4[医药卫生—心血管疾病]