妊娠期高血压患者胎盘绒毛组织氧化应激状态的改变  

Study on oxidative stress in placental villus of patients with hypertensive disorder complicating pregnancy

作　　者：邰贺[1] 王丹[2] 梁艳[2] 戴红[1] 闫大晶[1] 王俭[1] 

机构地区：[1]武警辽宁总队医院妇产科,辽宁沈阳110034 [2]武警总医院,北京100039

出　　处：《武警后勤学院学报（医学版）》2013年第11期976-978,共3页Journal of Logistics University of PAP（Medical Sciences）

摘　　要：【目的】探讨妊娠高血压患者胎盘绒毛组织氧化应激状态的改变。【方法】收集42名妊娠期高血压、子痫前期患者与20名正常妊娠足月孕妇胎盘绒毛组织。检测胎盘绒毛组织中谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-PX)、超氧化物歧化酶(superoxide dismutase,SOD)活性和同型半胱氨酸(homocysteic acid,Hcy)。【结果】妊娠期高血压疾病组胎盘绒毛组织GSH-PX活性([21.52±7.67)U/mg]显著低于正常妊娠组([25.13±21.26)U/mg,P<0.01],妊娠期高血压疾病组SOD活性([218.32±15.46)U/mg]显著低于正常妊娠组([245.63±28.31)U/mg,P<0.01],妊娠期高血压疾病组Hcy([15.37±3.61)μmol/mg]显著高于正常妊娠组([13.95±2.38)μmol/mg,P<0.01],且妊娠高血压疾病组Hcy与SOD呈负相关(r=-0.825,P<0.05)。【结论】妊娠期高血压疾病胎盘绒毛组织中氧化物质增多,抗氧化酶活性降低,氧化还原系统平衡失调,呈现氧化应激状态。[Objective] To explore the oxidative stress in placental villus of patients with hypertensive disorder complicating pregnancy. [Methods] The placental villus of 42 women （gestational hypertension and preeclampsia） and 20 normal pregnant of full term were collected, and the activity of GSH-PX, SOD and the concentration of Hcy in placental villus were decteded. [Results] The activity of GSH-PX in placental villus was markedly lower in hypertensive disorder complicating pregnancy [（21.52 ±7.67） U/mg] than in normal pregnancy [（25.13 ±21.26） U/mg, P〈0.01]. The activity of SOD in placental villus was markedly lower in hypertensived isorder omplicating pregnancy [（218.32 ±15.46） U/mg] than in normal pregnancy [（245.63 ±28.31） U/mg, P 〈 0.01]. The concentration of Hcy in placental villus of hypertensive disorder complicating pregnancy [（15.37± 3.61） μmol/mg] was more than normal pregnaney[（l 3.95 ±2.38） μmol/mg, P 〈 0.01] . In addition, the level of Hcy had positive relationship with the activity of SOD in placental villus of hypertensive disorder complicating pregnancy（r -= -0.825, P 〈 0.05）. [Conclusions] Hypertensive disorder complicating pregnancy can increse oxidant and decrease antioxidant.

关 键 词：妊娠期高血压 氧化应激 胎盘绒毛 

分 类 号：R714.246[医药卫生—妇产科学]